Comparison between [68Ga]Ga-PSMA-617 and [18F]FET PET as Imaging Biomarkers in Adult Recurrent Glioblastoma

被引:7
作者
Brighi, Caterina [1 ]
Puttick, Simon [2 ]
Woods, Amanda [3 ]
Keall, Paul [1 ]
Tooney, Paul A. [4 ]
Waddington, David E. J. [1 ]
Sproule, Vicki [3 ]
Rose, Stephen [2 ]
Fay, Michael [3 ,4 ]
机构
[1] Univ Sydney, Image X Inst, Fac Med & Hlth, Sydney Sch Hlth Sci, Sydney 2015, Australia
[2] AdvanCell Isotopes Pty Ltd, Sydney 2000, Australia
[3] GenesisCare, Newcastle 2290, Australia
[4] Univ Newcastle, Coll Hlth Med & Wellbeing, MHF Ctr Brain Canc Res, Newcastle 2308, Australia
关键词
Ga-68]Ga-PSMA-617; recurrent glioblastoma; positron emission tomography imaging of glioblastoma; theranostics for glioblastoma; MEMBRANE ANTIGEN; PROSTATE-CANCER; DIAGNOSIS; ANGIOGENESIS; EXPRESSION; TRACERS; GRADE;
D O I
10.3390/ijms242216208
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aim of this prospective clinical study was to evaluate the potential of the prostate specific membrane antigen (PSMA) targeting ligand, [Ga-68]-PSMA-Glu-NH-CO-NH-Lys-2-naphthyl-L-Ala-cyclohexane-DOTA ([Ga-68]Ga-PSMA-617) as a positron emission tomography (PET) imaging biomarker in recurrent glioblastoma patients. Patients underwent [Ga-68]Ga-PSMA-617 and O-(2-[F-18]-fluoroethyl)-L-tyrosine ([F-18]FET) PET scans on two separate days. [Ga-68]Ga-PSMA-617 tumour selectivity was assessed by comparing tumour volume delineation and by assessing the intra-patient correlation between tumour uptake on [Ga-68]Ga-PSMA-617 and [F-18]FET PET images. [Ga-68]Ga-PSMA-617 tumour specificity was evaluated by comparing its tumour-to-brain ratio (TBR) with [F-18]FET TBR and its tumour volume with the magnetic resonance imaging (MRI) contrast-enhancing (CE) tumour volume. Ten patients were recruited in this study. [Ga-68]Ga-PSMA-617-avid tumour volume was larger than the [F-18]FET tumour volume (p = 0.063). There was a positive intra-patient correlation (median Pearson r = 0.51; p < 0.0001) between [Ga-68]Ga-PSMA-617 and [F-18]FET in the tumour volume. [Ga-68]Ga-PSMA-617 had significantly higher TBR (p = 0.002) than [F-18]FET. The [Ga-68]Ga-PSMA-617-avid tumour volume was larger than the CE tumour volume (p = 0.0039). Overall, accumulation of [Ga-68]-Ga-PSMA-617 beyond [F-18]FET-avid tumour regions suggests the presence of neoangiogenesis in tumour regions that are not overly metabolically active yet. Higher tumour specificity suggests that [Ga-68]-Ga-PSMA-617 could be a better imaging biomarker for recurrent tumour delineation and secondary treatment planning than [F-18]FET and CE MRI.
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页数:15
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