Bone marrow aspirate concentrate chondroplasty to delaying need for total knee arthroplasty: a retrospective review of a veteran cohort

被引:1
作者
Pearl, Adam [1 ,2 ,3 ]
Saleh, Khaled [1 ,2 ]
Korsog, Diana [1 ]
Mundt, Jeffery [1 ]
机构
[1] John Dingell VAMC, Detroit, MI 48201 USA
[2] Fajr Sci, Ann Arbor, MI 48103 USA
[3] HCA Florida Aventura Hosp, Dept Emergency Med, Aventura, FL 33180 USA
关键词
bone marrow; chondroplasty; joint preservation; regenerative medicine; total knee arthroplasty; MESENCHYMAL STEM-CELLS; HYALURONIC-ACID; OSTEOARTHRITIS; DIFFERENTIATION; POPULATION; INJECTION; SEVERITY; EFFICACY; SALINE; PAIN;
D O I
10.2217/rme-2023-0124
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Aim: Osteoarthritis (OA) is a highly prevalent and costly condition, rooted in cartilaginous defects. Despite various causes, the inability for chondrocytes to regenerate prohibits these lesions from self-healing. Debridement commonly provides symptomatic relief but does not target the underlying disease process, necessitating investigation into possible treatments. Intraosseous and intraarticular bone marrow aspirate concentrate (BMAC) injection is a new promising therapy aimed at repairing these cartilage defects. Methods/materials: We retrospectively reviewed patients who underwent BMAC chondroplasty and examined the efficacy in delaying need for further intervention. Results: Only 5 of 23 procedures (21.7%) required postoperative intervention within the 2-year follow-up period. Only one request for total knee arthroplasty was made, but the procedure has not been done. Conclusion: This study demonstrates that BMAC chondroplasty may be an efficacious method to delay need for total knee arthroplasty.
引用
收藏
页码:833 / 838
页数:6
相关论文
共 22 条
[1]   Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: A systematic review and meta-analysis [J].
Bannuru, Raveendhara R. ;
Vaysbrot, Elizaveta E. ;
Sullivan, Matthew C. ;
McAlindon, Timothy E. .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2014, 43 (05) :593-599
[2]   The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study [J].
Bayliss, Lee E. ;
Culliford, David ;
Monk, A. Paul ;
Glyn-Jones, Sion ;
Prieto-Alhambra, Daniel ;
Judge, Andrew ;
Cooper, Cyrus ;
Carr, Andrew J. ;
Arden, Nigel K. ;
Beard, David J. ;
Price, Andrew J. .
LANCET, 2017, 389 (10077) :1424-1430
[3]   The natural history of cartilage defects in people with knee osteloarthritis [J].
Davies-Tuck, M. L. ;
Wluka, Anita ;
Wang, Y. ;
Teichtahl, A. J. ;
Ding, C. ;
Cicuttini, Flavia M. .
OSTEOARTHRITIS AND CARTILAGE, 2008, 16 (03) :337-342
[4]   Clinical outcomes after arthroscopic treatment of knee osteoarthritis [J].
Figueroa, David ;
Calvo, Rafael ;
Villalon, Ignacio E. ;
Melean, Patricio ;
Novoa, Felipe ;
Vaisman, Alex .
KNEE, 2013, 20 (06) :591-594
[5]   A prospective randomised trial comparing intra-articular Hyalgan injection and arthroscopic washout for knee osteoarthritis [J].
Forster, MC ;
Straw, R .
KNEE, 2003, 10 (03) :291-293
[6]   In knee OA, intraarticular triamcinolone increased cartilage loss and did not differ from saline for knee pain [J].
Hart, Lawrence E. .
ANNALS OF INTERNAL MEDICINE, 2017, 167 (06) :JC27-JC27
[7]   Directing stem cell differentiation into the chondrogenic lineage in vitro [J].
Heng, BC ;
Cao, T ;
Lee, EH .
STEM CELLS, 2004, 22 (07) :1152-1167
[8]   The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: A 4-to 6-year symptomatic follow-up [J].
Jackson, RW ;
Dietrichs, C .
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2003, 19 (01) :13-20
[9]  
Koshino Tomihisa, 1993, Bulletin Hospital for Joint Diseases, V53, P41
[10]   Insurer and Out-of-Pocket Costs of Osteoarthritis in the US Evidence From National Survey Data [J].
Kotlarz, Harry ;
Gunnarsson, Candace L. ;
Fang, Hai ;
Rizzo, John A. .
ARTHRITIS AND RHEUMATISM, 2009, 60 (12) :3546-3553