Signaling pathways governing the behaviors of leukemia stem cells

被引：6

作者：

Azizidoost, Shirin ^{[1
]}

Nasrolahi, Ava ^{[2
]}

Sheykhi-Sabzehpoush, Mohadeseh ^{[3
]}

Anbiyaiee, Amir ^{[4
]}

Khoshnam, Seyed Esmaeil ^{[5
]}

Farzaneh, Maryam ^{[6
]}

Uddin, Shahab ^{[7
,8
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz 6193673111, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Infect Ophthalmol Res Ctr, Ahvaz 6193673111, Iran

[3] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Dept Lab, Tehran 2193672411, Iran

[4] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Surg, Ahvaz 6193673111, Iran

[5] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Persian Gulf Physiol Res Ctr, Ahvaz 6193673111, Iran

[6] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz 6193673111, Iran

[7] Hamad Med Corp, Translat Res Inst, Acad Hlth Syst, Doha 3050, Qatar

[8] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, Doha 3050, Qatar

来源：

GENES & DISEASES | 2024年 / 11卷 / 02期

关键词：

Leukemia; Leukemia stem cells; Pathogenesis; Signaling pathways; Stem cells; ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; GROWTH-FACTOR RECEPTOR; SELF-RENEWAL CAPACITY; BETA-CATENIN; TUMOR-SUPPRESSOR; INITIATING CELLS; HEDGEHOG PATHWAY; CML STEM; T-CELLS;

D O I：

10.1016/j.gendis.2023.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation, migration, EMT, and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal, metastasis, and tumorigenesis. 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/).

引用

页码：830 / 846

页数：17

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