Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway

被引：3

作者：

Zhao, Guozheng ^{[1
,2
]}

Deng, Zhitong ^{[1
,3
]}

Li, Xuetao ^{[1
]}

Wang, Hao ^{[1
]}

Chen, Guangliang ^{[1
]}

Feng, Ming ^{[1
]}

Zhou, Youxin ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215000, Peoples R China

[2] Suzhou Ninth Peoples Hosp, Dept Neurosurg, Suzhou 215000, Peoples R China

[3] Huzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Huzhou 313000, Peoples R China

来源：

EXPERIMENTAL BRAIN RESEARCH | 2023年 / 241卷 / 10期

关键词：

Glioma stem cells; EZH2; Notch1; STAT3; GSK126; ROLES; THERAPY;

D O I：

10.1007/s00221-023-06693-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through the activation of the STAT3 and Notch1 pathways. Furthermore, we demonstrated the effect of the EZH2-specific inhibitor GSK126 on GSCs; these results not only corroborate our hypothesis, but also provide a potential novel treatment approach for glioma.

引用

页码：2409 / 2418

页数：10

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