Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model

被引：1

作者：

Yin, Xin ^{[1
]}

Meng, Yiwei ^{[1
]}

Sun, Chenghong ^{[2
]}

Zhao, Yanqiu ^{[1
]}

Wang, Weitao ^{[1
]}

Zhao, Peipei ^{[1
]}

Wang, Mengmeng ^{[1
]}

Ren, Jingli ^{[1
]}

Yao, Jingchun ^{[2
]}

Zhang, Lixin ^{[1
,3
]}

Xia, Xuekui ^{[1
]}

机构：

[1] Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan 250013, Peoples R China

[2] Lunan Pharmaceut Grp Co LTD, State Key Lab Gener Manufacture Technol Chinese Tr, Linyi 276005, Peoples R China

[3] East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

BIOGERONTOLOGY | 2024年 / 25卷 / 03期

关键词：

Anti-aging; Anti-infection; Antioxidant; Caenorhabditis elegans; Jingfang Granule; Lifespan; LIFE-SPAN; HEALTHSPAN; INFECTION; PROMOTES;

D O I：

10.1007/s10522-023-10058-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Jingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the pharyngeal pumping rate or nematode motility. Moreover, JFG notably increased oviposition by 11.3%. Subsequent investigations revealed that JFG enhanced oxidative stress resistance in C. elegans by reducing reactive oxygen species levels and significantly improved survival rates in nematodes infected with Pseudomonas aeruginosa ATCC 9027. These findings suggest that JFG delays reproductive senescence in C. elegans and protects them from oxidative stress, thereby extending their lifespan. Additionally, JFG improves the survival of P. aeruginosa-infected nematodes. Consequently, JFG has potential as a candidate for the development of anti-aging and anti-infection functional medicines.

引用

页码：433 / 445

页数：13