Novel sulfonamide-functionalized arylidene indolones as potent a-glucosidase inhibitors: synthesis, characterization, and in vitro and in silico studies

被引：1
|
作者：
Nguyen, Giang V. [1 ]
Dang, Hoang T. [1 ]
Nguyen, Luyen D. [1 ]
Nguyen, Hai V. [1 ]
Le, Huong T. [1 ]
Nguyen, Huy H. N. [2 ]
Nguyen, An V. [2 ]
Nguyen, Yen H. [3 ]
Nguyen, Van-Ha [3 ]
Do, Huy-Hoang [3 ]
机构：
[1] Hanoi Univ Pharm, Hanoi 11021, Vietnam
[2] Nguyen Gia Thieu High Sch, Hanoi 11811, Vietnam
[3] Vietnam Natl Univ, Univ Sci, Fac Chem, Hanoi 11021, Vietnam
来源：
MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 04期
关键词：
indolones; arylidene indolones; sulfonamides; inhibitor; ALPHA-GLUCOSIDASE; SACCHAROMYCES-CEREVISIAE; ANTIMICROBIAL ACTIVITY; OXINDOLE DERIVATIVES; ANALOGS;
D O I：
10.1016/j.mencom.2023.06.033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit a-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 & mu;M.
引用
收藏
页码：543 / 545
页数：3
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