The role of m6A methylation in therapy resistance in cancer

被引：110
作者：
Zhuang, Hengzhao [1 ]
Yu, Bo [2 ]
Tao, Dan [3 ]
Xu, Xiaoyan [1 ]
Xu, Yijun [1 ]
Wang, Jian [2 ]
Jiao, Yang [4 ]
Wang, Lili [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Radiat Oncol, Suzhou 21500, Peoples R China
[2] Nantong Univ, Affiliated Jiangyin Peoples Hosp, Dept Radiotherapy, Jiangyin 214400, Peoples R China
[3] Soochow Univ, Dushu Lake Hosp, Dept Radiat Oncol, Suzhou 21500, Peoples R China
[4] Soochow Univ, Med Coll, Sch Radiat Med & Protect, Suzhou 215000, Peoples R China
来源：
MOLECULAR CANCER | 2023年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
m6A methylation; Cancer; Chemoresistance; Radiotherapy resistance; CELL LUNG-CANCER; CISPLATIN RESISTANCE; ACQUIRED-RESISTANCE; DRUG-RESISTANCE; MECHANISMS; RADIORESISTANCE; AUTOPHAGY; PROGRESSION; EXPRESSION; MET;
D O I：
10.1186/s12943-023-01782-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation. A large number of studies have shown that m6A RNA methylation regulates the proliferation and invasion of cancer cells, but the role of m6A in cancer therapy resistance is unclear. In this review, we summarized the research progress related to the role of m6A in regulating therapy resistance in cancers.
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页数：14
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