Gadolinium-enhanced intracranial aneurysm wall imaging and risk of aneurysm growth and rupture: a multicentre longitudinal cohort study

被引：5

作者：

van der Kamp, Laura T. ^{[1
]}

Edjlali, Myriam ^{[2
]}

Naggara, Olivier ^{[3
]}

Matsushige, Toshinori ^{[4
]}

Bulters, Diederik O. ^{[5
]}

Digpal, Ronneil ^{[5
]}

Zhu, Chengcheng ^{[6
]}

Saloner, David ^{[7
]}

Hu, Peng ^{[8
]}

Zhai, Xiaodong ^{[8
]}

Mossa-Basha, Mahmud ^{[6
,9
]}

Tian, Bing ^{[10
]}

Sakamoto, Shigeyuki ^{[11
]}

Fu, Qichang ^{[12
]}

Ruigrok, Ynte M. ^{[1
]}

Zhao, Huilin ^{[13
]}

Chen, Huijun ^{[14
]}

Rinkel, Gabriel J. E. ^{[1
]}

van der Schaaf, Irene C. ^{[15
]}

Vergouwen, Mervyn D. I. ^{[1
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Room G3-201,POB 85500, NL-3508 GA Utrecht, Netherlands

[2] Univ Paris Saclay, Hop Raymond Poincare & Ambroise Pare, APHP,GH Univ Paris Saclay,CEA,CNRS,Inserm,Service, DMU Smart Imaging,Lab Imagerie Biomed Multimodale, Orsay, France

[3] Univ Paris, Ctr Hosp Sainte Anne, Dept Neuroradiol, IMABRAIN,INSERM,UMR1266,DHU Neurovasc,GHU Paris, Paris, France

[4] Hiroshima City Asa Citizens Hosp, Dept Neurosurg & Intervent Neuroradiol, Hiroshima, Japan

[5] Univ Hosp Southampton NHS Fdn Trust, Dept Neurosurg, Southampton, England

[6] Univ Washington, Sch Med, Dept Radiol, Seattle, WA USA

[7] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[8] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China

[9] Univ N Carolina, Dept Radiol, Chapel Hill, NC USA

[10] Changhai Hosp, Dept Radiol, Shanghai, Peoples R China

[11] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Neurosurg & Intervent Neuroradiol, Hiroshima, Japan

[12] Zhengzhou Univ, Affiliated Hosp 1, Dept Magnet Resonance, Zhengzhou, Peoples R China

[13] Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Radiol, Shanghai, Peoples R China

[14] Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing, Peoples R China

[15] Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Radiol, Utrecht, Netherlands

来源：

EUROPEAN RADIOLOGY | 2024年 / 34卷 / 07期

关键词：

Brain; Intracranial aneurysm; Magnetic resonance imaging; Risk factors; PHASES SCORE; FOLLOW-UP; PREDICTION;

D O I：

10.1007/s00330-023-10388-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objectives In patients with an unruptured intracranial aneurysm, gadolinium enhancement of the aneurysm wall is associated with growth and rupture. However, most previous studies did not have a longitudinal design and did not adjust for aneurysm size, which is the main predictor of aneurysm instability and the most important determinant of wall enhancement. We investigated whether aneurysm wall enhancement predicts aneurysm growth and rupture during follow-up and whether the predictive value was independent of aneurysm size.Materials and methods In this multicentre longitudinal cohort study, individual patient data were obtained from twelve international cohorts. Inclusion criteria were as follows: 18 years or older with >= 1 untreated unruptured intracranial aneurysm < 15 mm; gadolinium-enhanced aneurysm wall imaging and MRA at baseline; and MRA or rupture during follow-up. Patients were included between November 2012 and November 2019. We calculated crude hazard ratios with 95%CI of aneurysm wall enhancement for growth (>= 1 mm increase) or rupture and adjusted for aneurysm size.Results In 455 patients (mean age (SD), 60 (13) years; 323 (71%) women) with 559 aneurysms, growth or rupture occurred in 13/194 (6.7%) aneurysms with wall enhancement and in 9/365 (2.5%) aneurysms without enhancement (crude hazard ratio 3.1 [95%CI: 1.3-7.4], adjusted hazard ratio 1.4 [95%CI: 0.5-3.7]) with a median follow-up duration of 1.2 years.Conclusions Gadolinium enhancement of the aneurysm wall predicts aneurysm growth or rupture during short-term follow-up, but not independent of aneurysm size.

引用

页码：4610 / 4618

页数：9

共 29 条

[11] Unruptured Intracranial Aneurysms Incidence of Rupture and Risk Factors [J].