Abnormalities in modular connectivity of functional brain networks and cognitive changes in patients with anti -N-methyl-D-aspartate receptor encephalitis

被引：0

作者：

Huang, Dongying ^{[1
]}

Lv, Caitiao ^{[1
]}

Chen, Zexiang ^{[1
]}

Li, Zhekun ^{[1
]}

Zheng, Jinou ^{[1
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Neurol, Nanning, Peoples R China

来源：

BRAIN RESEARCH | 2023年 / 1820卷

关键词：

Anti-N-methyl-D-aspartate receptor; encephalitis; Functional connection; Modularity; Graph theory; SEGREGATION; DEFICITS; CORTEX;

D O I：

10.1016/j.brainres.2023.148605

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To explore potential mechanisms of cognitive changes in patients with anti-NMDAR encephalitis (ANMDARE) from intramodule and intermodule effects of brain functional networks. Methods: Resting-state functional MRI(rs-fMRI) imaging data was collected from 30 ANMDARE and 30 healthy controls (HCs). A brain functional matrix was constructed, and sparsity was established by module similarity. For both groups, changes in functional connectivity (FC) within and between modules was calculated, and wholebrain functional topology was analyzed. Finally, the association of brain functional with cognitive function in ANMDARE was further analyzed.Results: Compared to HCs, ANMDARE had enhanced connectivity within the modules that included the occipitoparietal-temporal and parahippocampal gyri. ANMDARE had significantly higher participation coefficients (PC) in the right inferior frontal gyrus than HCs and significantly lower PC in the left superior parietal lobule, left caudate nucleus, and right putamen. No statistically significant differences in global topological properties were found between the two groups. No correlations were found between functional and structural brain indicators and the Cognitive Assessment Scale and the Emotional Deficit Scale.Conclusions: Patients with ANMDARE are manifested by enhanced intramodular FC and intermodular connectivity changes in the brain. This may help to understand the pathophysiological mechanisms of the disease from a global perspective.

引用

页数：8

共 46 条

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