Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives

被引：41

作者：

Wang, Yu ^{[1
,2
]}

Jin, Mingyue ^{[1
]}

Cheng, Chak Kwong ^{[3
]}

Li, Qiang ^{[1
]}

机构：

[1] Shenzhen Univ, Dept Endocrinol & Metab, Gen Hosp, Shenzhen, Guangdong, Peoples R China

[2] City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷

关键词：

tubular injury; diabetic kidney disease; mechanism; therapy; programmed cell death; stem cell; ENDOPLASMIC-RETICULUM STRESS; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS; MINERALOCORTICOID RECEPTOR; PROXIMAL TUBULE; DIPEPTIDYL PEPTIDASE-4; SGLT2; INHIBITORS; EPITHELIAL-CELLS; ANGIOTENSIN-II; AUTOPHAGY;

D O I：

10.3389/fendo.2023.1238927

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs available for DKD. While previous research has primarily focused on glomerular injury, recent studies have increasingly emphasized the role of renal tubular injury in the pathogenesis of DKD. Various factors, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death, have been shown to induce renal tubular injury and contribute to the progression of DKD. Additionally, traditional hypoglycemic drugs, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have demonstrated their potential to alleviate renal tubular injury in DKD. This review will provide insights into the latest research on the mechanisms and treatments of renal tubular injury in DKD.

引用

页数：19

共 238 条

[1] Pyroptosis in diabetic nephropathy [J].

Al Mamun, Abdullah ;

Mimi, Anjuman Ara ;

Wu, Yanqing ;

Zaeem, Muhammad ;

Aziz, Md. Abdul ;

Suchi, Suzia Aktar ;

Alyafeai, Eman ;

Munir, Fahad ;

Xiao, Jian .

CLINICA CHIMICA ACTA, 2021, 523 :131-143

[2] Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression [J].

Al-Dabet, Moh'd Mohanad ;

Shahzad, Khurrum ;

Elwakiel, Ahmed ;

Sulaj, Alba ;

Kopf, Stefan ;

Bock, Fabian ;

Gadi, Ihsan ;

Zimmermann, Silke ;

Rana, Rajiv ;

Krishnan, Shruthi ;

Gupta, Dheerendra ;

Manoharan, Jayakumar ;

Fatima, Sameen ;

Nazir, Sumra ;

Schwab, Constantin ;

Baber, Ronny ;

Scholz, Markus ;

Geffers, Robert ;

Mertens, Peter Rene ;

Nawroth, Peter P. ;

Griffin, John H. ;

Keller, Maria ;

Dockendorff, Chris ;

Kohli, Shrey ;

Isermann, Berend .

NATURE COMMUNICATIONS, 2022, 13 (01)

[3] High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases [J].

Allen, DA ;

Harwood, SM ;

Varagunam, M ;

Raftery, MJ ;

Yaqoob, MM .

FASEB JOURNAL, 2003, 17 (03) :908-+

[4] Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model [J].

An, Xingxing ;

Liao, Guangneng ;

Chen, Younan ;

Luo, Ai ;

Liu, Jingping ;

Yuan, Yujia ;

Li, Lan ;

Yang, Lichuan ;

Wang, Hong ;

Liu, Fang ;

Yang, Guang ;

Yi, Shounan ;

Li, Yuanmin ;

Cheng, Jingqiu ;

Lu, Yanrong .

STEM CELL RESEARCH & THERAPY, 2019, 10 (01)

[5] Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging [J].

Baar, Marjolein P. ;

Brandt, Renata M. C. ;

Putavet, Diana A. ;

Klein, Julian D. D. ;

Derks, Kasper W. J. ;

Bourgeois, Benjamin R. M. ;

Stryeck, Sarah ;

Rijksen, Yvonne ;

van Willigenburg, Hester ;

Feijtel, Danny A. ;

van der Pluijm, Ingrid ;

Essers, Jeroen ;

van Cappellen, Wiggert A. ;

van IJcken, Wilfred F. ;

Houtsmuller, Adriaan B. ;

Pothof, Joris ;

de Bruin, Ron W. F. ;

Madl, Tobias ;

Hoeijmakers, Jan H. J. ;

Campisi, Judith ;

de Keizer, Peter L. J. .

CELL, 2017, 169 (01) :132-+

[6] Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes [J].

Bakris, George L. ;

Agarwal, Rajiv ;

Anker, Stefan D. ;

Pitt, Bertram ;

Ruilope, Luis M. ;

Rossing, Peter ;

Kolkhof, Peter ;

Nowack, Christina ;

Schloemer, Patrick ;

Joseph, Amer ;

Filippatos, Gerasimos .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2219-2229

[7] INHIBITION OF CELLULAR AUTOPHAGY IN PROXIMAL TUBULAR CELLS OF THE KIDNEY IN STREPTOZOTOCIN-DIABETIC AND UNINEPHRECTOMIZED RATS [J].

BARBOSA, AD ;

ZHOU, H ;

HULTENSCHMIDT, D ;

TOTOVIC, V ;

JURILJ, N ;

PFEIFER, U .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1992, 61 (06) :359-366

[8] 1,25-dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism [J].

Barthel, Thomas K. ;

Mathern, Douglas R. ;

Whitfield, G. Kerr ;

Haussler, Carol A. ;

Hopper, H. Andrew ;

Hsieh, Jui-Cheng ;

Slater, Stephanie A. ;

Hsieh, Grace ;

Kaczmarska, Magdalena ;

Jurutka, Peter W. ;

Kolek, Olga I. ;

Ghishan, Fayez K. ;

Haussler, Mark R. .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 103 (3-5) :381-388

[9] Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease [J].

Bejoy, Julie ;

Farry, Justin M. ;

Peek, Jennifer L. ;

Cabatu, Mariana C. ;

Williams, Felisha M. ;

Welch, Richard C. ;

Qian, Eddie S. ;

Woodard, Lauren E. .

STEM CELL RESEARCH & THERAPY, 2022, 13 (01)

[10] Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery [J].

Benedetti, Valentina ;

Brizi, Valerio ;

Guida, Patrizia ;

Tomasoni, Susanna ;

Ciampi, Osele ;

Angeli, Elena ;

Valbusa, Ugo ;

Benigni, Ariela ;

Remuzzi, Giuseppe ;

Xinaris, Christodoulos .

EBIOMEDICINE, 2018, 33 :253-268

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