Pulmonary hypertension in preterm infants with moderate-to-severe bronchopulmonary dysplasia (BPD)

被引:5
作者
Branescu, Irina [1 ,2 ]
Shetty, Sandeep [1 ]
Richards, Justin [1 ]
Vladareanu, Simona [2 ]
Kulkarni, Anay [1 ,3 ]
机构
[1] St Georges Univ, St Georges Hosp, Neonatal Intens Care Unit, London, England
[2] Carol Davila Univ Med & Pharm, Elias Univ Hosp, Neonatal Intens Care Unit, Bucharest, Romania
[3] Royal Brompton Hosp NHS Fdn Trust, London, England
关键词
bronchopulmonary dysplasia with pulmonary hypertension; echocardiography; extreme prematurity; pulmonary hypertension; PREMATURE-INFANTS; VASCULAR-DISEASE; OUTCOMES; IMPACT;
D O I
10.1111/apa.16863
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aim: To describe clinical characteristics of pulmonary hypertension (PH) associated with moderate to severe BPD (MSBPD) in premature infants born =32 weeks gestation.Methods: This was a single centre retrospective cohort study, with reanalysis of echo cardiographic studies for PH of infants born =32 weeks gestation with MSBPD admit- ted to a tertiary surgical neonatal service.Results: In total, 268 babies with MSBPD were included in the study. Incidence of BPD-associated PH (BPD PH) was 12.6% (34), of which 41% infants were observed to have severe PH. On multivariate analysis, need for positive pressure respiratory support at 36 weeks post menstrual age (PMA) was independently associated with PH (p = 0.001; 95% CI 2- 13.5) Presence of PH and severity of PH were associated with increased mortality. Of babies with MSBPD- PH, 32% died before discharge from the neonatal unit.Conclusion: Babies with MSBPD and PH are more likely to die before discharge from the neonatal unit. Need for positive pressure respiratory support at 36 weeks PMA is independently associated with PH. Babies with MSBPD with less than severe PH are also associated with increased mortality when compared to babies with MSBPD with no PH.
引用
收藏
页码:1877 / 1883
页数:7
相关论文
共 21 条
[1]  
An Hyo Soon, 2010, Korean Circ J, V40, P131, DOI 10.4070/kcj.2010.40.3.131
[2]   Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age [J].
Arjaans, Sanne ;
Haarman, Meindina G. ;
Roofthooft, Marcus T. R. ;
Fries, Marian W. F. ;
Kooi, Elisabeth M. W. ;
Bos, Arend F. ;
Berger, Rolf M. F. .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2021, 106 (01) :F45-F50
[3]  
Bhat R., 2013, J NEONATOL, V27, P46, DOI [10.1177/0973217920130111, DOI 10.1177/0973217920130111]
[4]   Reliability of Echocardiographic Indicators of Pulmonary Vascular Disease in Preterm Infants at Risk for Bronchopulmonary Dysplasia [J].
Carlton, Erin F. ;
Sontag, Marci K. ;
Younoszai, Adel ;
DiMaria, Michael V. ;
Miller, Joshua I. ;
Poindexter, Brenda B. ;
Abman, Steven H. ;
Mourani, Peter M. .
JOURNAL OF PEDIATRICS, 2017, 186 :29-33
[5]   Risk Factors and Outcomes of Pulmonary Hypertension in Infants With Bronchopulmonary Dysplasia: A Meta-Analysis [J].
Chen, Ying ;
Zhang, Di ;
Li, Ying ;
Yan, Aixia ;
Wang, Xiaoying ;
Hu, Xiaoming ;
Shi, Hangting ;
Du, Yue ;
Zhang, Wenhui .
FRONTIERS IN PEDIATRICS, 2021, 9
[6]   Intravitreal dexamethasone implant for central retinal vein occlusion without macular edema [J].
Choi, Eun Young ;
Kang, Hyun Goo ;
Lee, Sung Chul ;
Kim, Min .
BMC OPHTHALMOLOGY, 2019, 19 (1)
[7]  
GORENFLO M, 1991, Pediatric Pathology, V11, P851
[8]   Pulmonary hypertension in bronchopulmonary dysplasia [J].
Hansmann, Georg ;
Sallmon, Hannes ;
Roehr, Charles C. ;
Kourembanas, Stella ;
Austin, Eric D. ;
Koestenberger, Martin .
PEDIATRIC RESEARCH, 2021, 89 (03) :446-455
[9]   Pulmonary Hypertension in Bronchopulmonary Dysplasia: Clinical Findings, Cardiovascular Anomalies and Outcomes [J].
Jesus del Cerro, Maria ;
Sabate Rotes, Anna ;
Carton, Antonio ;
Deiros, Lucia ;
Bret, Montserrat ;
Cordeiro, Malaika ;
Verdu, Cristina ;
Isabel Barrios, Maria ;
Albajara, Luis ;
Gutierrez-Larraya, Federico .
PEDIATRIC PULMONOLOGY, 2014, 49 (01) :49-59
[10]  
Jobe AH., 2006, NEOREVIEWS, V7, P10