Immunomodulatory and Anti-inflammatory effect of Neural Stem/Progenitor Cells in the Central Nervous System

被引:15
作者
Ni, Wei [1 ,2 ]
Ramalingam, Murugan [3 ,4 ,5 ,6 ]
Li, Yumeng [3 ,4 ,5 ]
Park, Jeong-Hui [3 ,4 ,5 ]
Dashnyam, Khandmaa [3 ]
Lee, Jung-Hwan [3 ,4 ,5 ]
Bloise, Nora [7 ,8 ]
Fassina, Lorenzo [9 ]
Visai, Livia [7 ,8 ]
De Angelis, Maria Gabriella Cusella [10 ]
Pedraz, Jose Luis [11 ,12 ]
Kim, Hae-Won [3 ,4 ,5 ]
Hu, Jiabo [2 ]
机构
[1] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Clin Lab, Changzhou 213000, Jiangsu, Peoples R China
[2] Jiangsu Univ, Sch Med, Jiangsu Key Lab Med Sci & Lab Med, Zhenjiang 212013, Jiangsu, Peoples R China
[3] Dankook Univ, Inst Tissue Regenerat Engn, Cheonan 31116, South Korea
[4] Dankook Univ, BK21 NBM Global Res Ctr Regenerat Med, Dept Nanobiomed Sci, Cheonan 31116, South Korea
[5] Dankook Univ, Mechanobiol Dent Med Res Ctr, Cheonan 31116, South Korea
[6] Chengdu Univ, Sch Basic Med Sci, Chengdu 610106, Peoples R China
[7] Univ Pavia, Ctr Hlth Technol CHT, Dept Mol Med, INSTM UdR Pavia, I-27100 Pavia, Italy
[8] IRCCS, UOR5 Lab Nanotecnol, Med Clin Specialist, ICS Maugeri, I-27100 Pavia, Italy
[9] Univ Pavia, Dept Elect Comp & Biomed Engn, I-27100 Pavia, Italy
[10] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Human Anat Unit, I-27100 Pavia, Italy
[11] Univ Basque Country UPV EHU, Fac Pharm, Lab Pharm & Pharmaceut Technol, NanoBioCel Res Grp, Vitoria 01006, Spain
[12] Inst Hlth Carlos III, Networking Res Ctr Bioengn Biomat & Nanomed, Madrid 28029, Spain
基金
新加坡国家研究基金会; 中国国家自然科学基金;
关键词
Neural stem; progenitor cells; immunomodulation; immune cells; neuroinflammation; extracellular vesicles; Genetic engineering; SPINAL-CORD-INJURY; STEM-CELLS; EXTRACELLULAR VESICLES; PRECURSOR CELLS; CROSS-TALK; MICROGLIAL POLARIZATION; ISCHEMIA-REPERFUSION; CHEMOKINE RECEPTORS; FUNCTIONAL RECOVERY; IMMUNE CELLS;
D O I
10.1007/s12015-022-10501-1
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Neuroinflammation is a critical event that responds to disturbed homeostasis and governs various neurological diseases in the central nervous system (CNS). The excessive inflammatory microenvironment in the CNS can adversely affect endogenous neural stem cells, thereby impeding neural self-repair. Therapies with neural stem/progenitor cells (NSPCs) have shown significant inhibitory effects on inflammation, which is mainly achieved through intercellular contact and paracrine signalings. The intercellular contact between NSPCs and immune cells, the activated CNS- resident microglia, and astrocyte plays a critical role in the therapeutic NSPCs homing and immunomodulatory effects. Moreover, the paracrine effect mainly regulates infiltrating innate and adaptive immune cells, activated microglia, and astrocyte through the secretion of bioactive molecules and extracellular vesicles. However, the molecular mechanism involved in the immunomodulatory effect of NSPCs is not well discussed. This article provides a systematic analysis of the immunomodulatory mechanism of NSPCs, discusses efficient ways to enhance its immunomodulatory ability, and gives suggestions on clinical therapy.
引用
收藏
页码:866 / 885
页数:20
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