Bacillus Calmette-Guerin pneumonitis after intravesical instillation: Report of two cases and a review of the literature

被引：0

作者：

Spisarova, Martina ^{[1
,2
]}

Losse, Stanislav ^{[2
,3
]}

Jakubec, Petr ^{[2
,3
]}

Hartmann, Igor ^{[2
,4
]}

Kral, Milan ^{[2
,4
]}

Ehrmann, Jiri ^{[2
,5
]}

Szkorupa, Marek ^{[2
,6
]}

Studentova, Hana ^{[1
,2
]}

Melichar, Bohuslav ^{[1
,2
]}

机构：

[1] Palacky Univ Olomouc, Fac Med & Dent, Dept Oncol, Olomouc, Czech Republic

[2] Univ Hosp Olomouc, Olomouc, Czech Republic

[3] Palacky Univ Olomouc, Fac Med & Dent, Dept Pneumol & TB, Olomouc, Czech Republic

[4] Palacky Univ Olomouc, Fac Med & Dent, Dept Urol, Olomouc, Czech Republic

[5] Palacky Univ Olomouc, Inst Mol & Clin Pathol, Fac Med & Dent, Olomouc, Czech Republic

[6] Palacky Univ Olomouc, Fac Med & Dent, Dept Surg 1, Olomouc, Czech Republic

来源：

BIOMEDICAL PAPERS-OLOMOUC | 2024年 / 168卷 / 02期

关键词：

bacillus Calmette-Gu?rin; bladder cancer; intravesical therapy; TRANSITIONAL-CELL-CARCINOMA; MYCOBACTERIUM-BOVIS; BCG THERAPY; GRANULOMATOUS PNEUMONITIS; BLADDER; COMPLICATIONS; INFECTION; HEPATITIS; IMMUNOTHERAPY; SECONDARY;

D O I：

10.5507/bp.2022.051

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Objective. Intravesical administration of bacillus Calmette-Guerin is standard adjuvant treatment of non-muscle inva-sive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications.Methods. We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer.Results. Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered.Conclusion. BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.

引用

页码：181 / 186

页数：6

共 52 条

[1] Pulmonary manifestations of urothelial carcinoma of the bladder [J].