Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features

被引：42

作者：

Capece, Umberto ^{[1
,2
]}

Moffa, Simona ^{[1
,2
]}

Improta, Ilaria ^{[1
,2
]}

Di Giuseppe, Gianfranco ^{[1
,2
]}

Nista, Enrico Celestino ^{[2
,3
]}

Cefalo, Chiara M. A. ^{[1
,2
]}

Cinti, Francesca ^{[1
,2
]}

Pontecorvi, Alfredo ^{[1
,2
]}

Gasbarrini, Antonio ^{[2
,3
]}

Giaccari, Andrea ^{[1
,2
]}

Mezza, Teresa ^{[2
,3
]}

机构：

[1] Fdn Policlin Univ Agostino Gemelli IRCCS, Endocrinol & Diabetol Unit, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy

[3] Fdn Policlin Univ Agostino Gemelli IRCCS, Digest Dis Ctr, I-00168 Rome, Italy

来源：

NUTRIENTS | 2023年 / 15卷 / 01期

关键词：

alpha-lipoic; glucose metabolism; diabetes prevention; complications; INSULIN-AUTOIMMUNE-SYNDROME; POLYCYSTIC-OVARY-SYNDROME; ACTIVATED PROTEIN-KINASE; TYPE-2; DIABETES-MELLITUS; SYNDROME HIRATA-DISEASE; D-CHIRO-INOSITOL; OXIDATIVE STRESS; AUTONOMIC NEUROPATHY; HEPATIC INFLAMMATION; SKELETAL-MUSCLE;

D O I：

10.3390/nu15010018

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS.

引用

页数：19