Eliminating COVID-19 as the immediate culprit for igniting pancreatitis

被引：3

作者：

Ge, Peng ^{[1
,2
,3
]}

Luo, Yalan ^{[1
,2
,3
]}

Liu, Jie ^{[1
,2
,3
]}

Liu, Jin ^{[1
,3
]}

Wen, Haiyun ^{[1
,2
,3
]}

Zhang, Guixin ^{[1
,2
,3
]}

Chen, Hailong ^{[1
,2
,3
,4
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian, Peoples R China

[2] Dalian Med Univ, Inst Coll Integrat Med, Dalian, Peoples R China

[3] Dalian Med Univ, Affiliated Hosp 1, Lab Integrat Med, Dalian, Peoples R China

[4] Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian 116011, Liaoning, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2023年 / 95卷 / 12期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

COVID-19; genetic variation; Mendelian randomization; pancreatitis; risk; MENDELIAN RANDOMIZATION; INSTRUMENTS; ASSOCIATION; OUTCOMES; BIAS;

D O I：

10.1002/jmv.29272

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID-19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID-19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID-19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID-19 and CP. A direct causal relationship between genetically predicted COVID-19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID-19 as a definitive cause of pancreatitis.

引用

页数：11

共 66 条

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