Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

被引：4
作者：
Nguyen, Khoa D. [1 ,2 ]
Amerio, Andrea [3 ,4 ]
Aguglia, Andrea [3 ,4 ]
Magnani, Luca [5 ]
Parise, Alberto [6 ]
Conio, Benedetta [3 ,4 ]
Serafini, Gianluca [3 ,4 ]
Amore, Mario [3 ,4 ]
Costanza, Alessandra [7 ,8 ,9 ]
机构：
[1] Stanford Univ, Dept Microbiol & Immunol, Palo Alto, CA 94305 USA
[2] Tranquis Therapeut, Palo Alto, CA 94065 USA
[3] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Sect Psychiat, I-16126 Genoa, Italy
[4] IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy
[5] San Maurizio Hosp Bolzano, Dept Psychiat, I-39100 Bolzano, Italy
[6] Univ Hosp Parma, Geriatr Rehabil Dept, I-43126 Parma, Italy
[7] Univ Hosp Geneva HUG, Dept Psychiat, Adult Psychiat Serv, CH-1207 Geneva, Switzerland
[8] Univ Italian Switzerland USI, Fac Biomed Sci, Dept Psychiat, CH-6900 Lugano, Switzerland
[9] Univ Geneva UNIGE, Fac Med, Dept Psychiat, CH-1211 Geneva, Switzerland
来源：
CELLS | 2023年 / 12卷 / 16期
关键词：
schizophrenia; microglia; neuroinflammation; immunological dysfunction; clinical correlates; IMPAIRED MONOCYTE ACTIVATION; T-CELLS; B-LYMPHOCYTES; DOUBLE-BLIND; DRUG-NAIVE; NEUTROPHIL/LYMPHOCYTE RATIO; 1ST-EPISODE PSYCHOSIS; DECREASED PRODUCTION; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION;
D O I：
10.3390/cells12162099
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.
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页数：22
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