Click synthesis, antimicrobial, DNA photocleavage and computational studies of oxindole-tethered 1H-1,2,3-triazoles

被引：12

作者：

Kumar, Vijay ^{[1
]}

Lal, Kashmiri ^{[1
]}

Kumar, Ravinder ^{[2
]}

Kumar, Anil ^{[2
]}

Mathpati, Ramling S. ^{[3
]}

Singh, Madhur Babu ^{[4
]}

Kumari, Kamlesh ^{[5
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India

[2] Guru Jambheshwar Univ Sci & Technol, Dept Bio & Nano Technol, Hisar 125001, Haryana, India

[3] Natl Inst Technol, Dept Chem, Kurukshetra 136119, Haryana, India

[4] Univ Delhi, Atma Ram Sanatan Dharma Coll, Dept Chem, New Delhi 110021, India

[5] Univ Delhi, Dept Zool, Delhi 110007, India

来源：

FUTURE MEDICINAL CHEMISTRY | 2023年 / 15卷 / 13期

关键词：

antimicrobial; click chemistry; DNA photocleavage; docking; 1; 2; 3-triazole; oxindole; x-ray diffraction; CYCLOADDITION EN-ROUTE; ANTIBACTERIAL; UPDATE; ISATIN; DERIVATIVES; ANTIFUNGAL; CHEMISTRY; DOCKING; DESIGN; ACID;

D O I：

10.4155/fmc-2023-0075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: To obtain new hybrids derived from isatin and triazole. Materials & methods: A series of oxindole-1-H-1,2,3-triazole hybrids (4a-l) were synthesized from 3-sulfenylated N-propargylated oxindoles and organic azides employing Cu(I)-catalyzed azide-alkyne cycloaddition. These compounds were evaluated in vitro for antimicrobial activity by the standard serial dilution method and DNA photocleavage activity. Results: Antimicrobial assay revealed that compounds 4l and 4f exhibited promising efficacy against Candida albicans and Rhizopus oryzae, respectively, with a minimum inhibitory concentration (MIC) value of 0.0008 & mu;mol/mL. Compounds 4h and 4k completely degraded plasmid DNA. Further molecular docking of compounds with 1KZN (4j and 4k) and 5TZ1 (4h and 4l) revealed good binding interactions. Conclusion: Results of the current research can help in the development of new antimicrobial agents with high efficacy.

引用

页码：1115 / 1131

页数：17

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