Autophagy in graves' ophthalmopathy

被引：3
作者：
Chen, Yu-Qing [1 ]
Gao, Lian-Di [2 ]
Liu, Yi-Lin [2 ]
Shen, Ya [1 ]
Diao, Jia-Le [1 ]
Yang, Wei-Hua [3 ]
Wei, Rui-Li [1 ]
机构：
[1] Naval Med Univ, Changzheng Hosp, Dept Ophthalmol, Shanghai, Peoples R China
[2] Naval Med Univ, Changzheng Hosp, Dept Nursing, Shanghai, Peoples R China
[3] Jinan Univ, Shenzhen Eye Hosp, Shenzhen, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
graves' ophthalmopathy; autophagy; inflammation; adipogenesis; glycosaminoglycan; ORBITAL FIBROBLASTS; ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; DISEASE; ORBITOPATHY; PATHOGENESIS; INFLAMMATION; TISSUE; ACTIVATION; DELETION;
D O I：
10.3389/fcell.2023.1158279
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Graves' ophthalmopathy (GO) is an inflammatory autoimmune disease that affects the eyes. It can significantly alter the quality of life in patients because of its distinctive pathological appearance and the effect on vision. To date, the exact pathological mechanism of GO has not been explicitly discovered. However, several studies have associated autophagy with this disease. Autophagy is a catabolic process that helps maintain homeostasis in all organisms by protecting the cells and tissues from various endogenous and exogenous stress factors. Based on our results, patients affected with GO have comparatively elevated levels of autophagy, which critically affects the pathological mechanism of the GO. In this review, we have summarized the autophagy mechanism in the pathogenesis of GO.
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页数：8
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共 95 条
  • [1] Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy
    Adornetto, Annagrazia
    Gesualdo, Carlo
    Lagana, Maria Luisa
    Trotta, Maria Consiglia
    Rossi, Settimio
    Russo, Rossella
    [J]. FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [2] Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    Amaravadi, Ravi K.
    Yu, Duonan
    Lum, Julian J.
    Bui, Thi
    Christophorou, Maria A.
    Evan, Gerard I.
    Thomas-Tikhonenko, Andrei
    Thompson, Craig B.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (02) : 326 - 336
  • [3] Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy
    Aniszewski, JP
    Valyasevi, RW
    Bahn, RS
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (02) : 776 - 780
  • [4] Current Insights into the Pathogenesis of Graves' Ophthalmopathy
    Bahn, R. S.
    [J]. HORMONE AND METABOLIC RESEARCH, 2015, 47 (10) : 773 - 778
  • [5] MECHANISMS OF DISEASE Graves' Ophthalmopathy
    Bahn, Rebecca S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (08) : 726 - 738
  • [6] Pathophysiology of Graves' ophthalmopathy: The cycle of disease
    Bahn, RS
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (05) : 1939 - 1946
  • [7] Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2
    Baird, Liam
    Suzuki, Takafumi
    Takahashi, Yushi
    Hishinuma, Eiji
    Saigusa, Daisuke
    Yamamoto, Masayuki
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2020, 40 (22)
  • [8] The contribution of immune regulatory and thyroid specific genes to the etiology of Graves' and Hashimoto's diseases
    Ban, YY
    Tomer, Y
    [J]. AUTOIMMUNITY, 2003, 36 (6-7) : 367 - 379
  • [9] The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy
    Bartalena, L.
    Kahaly, G. J.
    Baldeschi, L.
    Dayan, C. M.
    Eckstein, A.
    Marcocci, C.
    Marino, M.
    Vaidya, B.
    Wiersinga, W. M.
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2021, 185 (04) : G43 - G67
  • [10] Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells
    Baskaran, Rathinasamy
    Poornima, Paramasivan
    Priya, Lohanathan Bharathi
    Huang, Chih-Yang
    Padma, Viswanadha Vijaya
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2016, 83 : 1407 - 1413
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