Effects of Lactiplantibacillus plantarum FBT215 and prebiotics on the gut microbiota structure of mice

Imbalanced intestinal microbiota is associated with diseases, including inflammatory bowel disease and obesity, and diet can alter the structure of the gut microbiota. In this study, the effects of dietary treatments including the potential probiotic Lactiplantibacillus plantarum FBT215 with/without prebiotics on the intestinal microbiota composition of mice were investigated. Lactiplantibacillus plantarum FBT215 administration significantly decreased the Firmicutes/Bacteroidetes ratio and increased the abundance of Muribaculum and Duncaniella. The diversity within and between groups was measured according to alpha and beta diversity metrics, respectively. The Shannon index of alpha diversity decreased significantly in all treatment groups except the probiotic group, although this group showed an increase in the Chao1 index. Principal coordinate analysis of beta diversity showed that the groups had different species distributions. Finally, gamma-aminobutyric acid (GABA) concentration increased in groups fed L. plantarum FBT215. These findings improve our understanding of the association between the gut microbiota structure and specific probiotic/prebiotic-containing diets.