Redox Regulation of PTEN by Reactive Oxygen Species: Its Role in Physiological Processes

被引：12

作者：

Trinh, Vu Hoang ^{[1
,2
]}

Huu, Thang Nguyen ^{[1
]}

Sah, Dhiraj Kumar ^{[1
]}

Choi, Jin Myung ^{[1
]}

Yoon, Hyun Joong ^{[1
]}

Park, Sang Chul ^{[3
]}

Jung, Yu Seok ^{[4
]}

Lee, Seung-Rock ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Biochem, Dept Biomed Sci, Med Sch, Gwangju 501190, South Korea

[2] Pham Ngoc Thach Univ Med, Dept Oncol, Dept Med Sci, Ho Chi Minh City 700000, Vietnam

[3] Chonnam Natl Univ, Adv Inst Aging Sci, Future Life & Soc Res Ctr, Gwangju 61469, South Korea

[4] Chonnam Natl Univ, Med Sch, Gwangju 501190, South Korea

来源：

ANTIOXIDANTS | 2024年 / 13卷 / 02期

关键词：

PTEN; redox regulation; oxidative inhibition; ROS; cell signaling; TUMOR-SUPPRESSOR PTEN; PROTEIN-TYROSINE PHOSPHATASES; LEFT-VENTRICULAR FUNCTION; CEREBRAL-ISCHEMIA; HYDROGEN-PEROXIDE; MYOCARDIAL ISCHEMIA/REPERFUSION; PHOSPHATIDYLINOSITOL; 3-KINASE; REVERSIBLE INACTIVATION; SIGNALING PATHWAYS; AXON REGENERATION;

D O I：

10.3390/antiox13020199

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In addition, PTEN plays an essential role in other physiological events associated with cell growth demands, such as ischemia-reperfusion, nerve injury, and immune responsiveness. Therefore, recently, PTEN inhibition has emerged as a potential therapeutic intervention in these situations. Increasing evidence demonstrates that reactive oxygen species (ROS), especially hydrogen peroxide (H2O2), are produced and required for the signaling in many important cellular processes under such physiological conditions. ROS have been shown to oxidize PTEN at the cysteine residue of its active site, consequently inhibiting its function. Herein, we provide an overview of studies that highlight the role of the oxidative inhibition of PTEN in physiological processes.

引用

页数：17