Recent Advances in the Synthesis of Pyrazole Derivatives: A Review

被引：63

作者：

Ameziane El Hassani, Issam ^{[1
]}

Rouzi, Khouloud ^{[2
]}

Assila, Hamza ^{[1
]}

Karrouchi, Khalid ^{[2
]}

Ansar, M'hammed ^{[1
]}

机构：

[1] Mohammed V Univ Rabat, Fac Med & Pharm, Lab Med Chem, Rabat 10100, Morocco

[2] Mohammed V Univ Rabat, Fac Med & Pharm, Lab Analyt Chem & Bromatol, Rabat 10100, Morocco

来源：

REACTIONS | 2023年 / 4卷 / 03期

关键词：

pyrazole derivatives; synthesis; reactions; heterocyclic; recent advances; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; 1,3-DIKETONES; ALKYNES;

D O I：

10.3390/reactions4030029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyrazole, characterized by a five-membered heterocyclic structure featuring two neighboring nitrogen atoms, serves as a core element. Pyrazoles hold a privileged status as versatile frameworks in various sectors of the chemical industry, including medicine and agriculture. Previous reviews have extensively highlighted the significance of pyrazoles and their diverse biological activities, encompassing roles such as antituberculosis, antimicrobial, antifungal, anti-inflammatory, anticancer, and antidiabetic agents. Consequently, they have garnered substantial interest from researchers. The aim of this review is to offer a comprehensive overview of the published research related to the synthesis of pyrazole derivatives, encompassing a discussion of diverse methods for accessing the pyrazole moiety. These methods span from utilizing transition-metal catalysts and photoredox reactions to employing one-pot multicomponent processes, novel reactants, and innovative reaction types. It encompasses studies conducted by numerous scientists worldwide, showcasing collective efforts in advancing the methodologies and applications of pyrazole derivatives.

引用

页码：478 / 504

页数：27

共 55 条

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