First Macrocyclic 1,2,3-Triazolyl Uridine Analogues

被引：0

作者：

Andreeva, Olga, V ^{[1
]}

Belenok, Mayya G. ^{[1
]}

Garifullin, Bulat F. ^{[1
]}

Strobykina, Irina Yu. ^{[1
]}

Saifina, Liliya F. ^{[1
]}

Voloshina, Alexandra D. ^{[1
]}

Semenov, Vyacheslav E. ^{[1
]}

Kataev, Vladimir E. ^{[1
]}

机构：

[1] Russian Acad Sci, Arbuzov Inst Organ & Phys Chem, FRC Kazan Sci Ctr, Kazan 420088, Russia

来源：

MACROHETEROCYCLES | 2023年 / 16卷 / 01期

关键词：

Nucleoside analogues; macrocycles; uridine; 1; 2; 3-triazole; click chemistry; CuAAC reaction; NUCLEOSIDES; COMPOUND;

D O I：

10.6060/mhc224868a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two macrocyclic 1,2,3-triazolyl uridine analogues were obtained for the first time by a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. A 29-membered macrocycle consisted of one uracil molecule, two D-ribofuranose molecules and four 1,2,3-triazole molecules. A 58-membered macrocycle consisted of two uracil mol-ecules, four D-ribofuranose molecules and eight 1,2,3-triazole molecules. Both macro cycles demonstrated moderate cytotoxicity against eight human cancer cell lines and normal cell line WI-38.

引用

页码：77 / 83

页数：7

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