ROS/RNS as molecular signatures of chronic liver diseases

被引：45

作者：

Che, Zhaodi ^{[1
]}

Zhou, Ziyuan ^{[2
]}

Li, Si-Qi ^{[3
]}

Gao, Lei ^{[4
]}

Xiao, Jia ^{[5
]}

Wong, Nai-Kei ^{[3
]}

机构：

[1] Jinan Univ, Clin Res Inst, Inst Obes & Metab, Affiliated Hosp 1, Guangzhou 510000, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp & Shenzhen Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Shenzhen 518116, Peoples R China

[3] Shantou Univ, Dept Pharmacol, Clin Pharmacol Sect, Med Coll, Shantou 515041, Peoples R China

[4] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510000, Peoples R China

[5] Univ Hlth & Rehabil Sci, Qingdao Hosp, Shandong Prov Key Lab Clin Res Liver Dis, Qingdao 266001, Peoples R China

来源：

TRENDS IN MOLECULAR MEDICINE | 2023年 / 29卷 / 11期

基金：

中国国家自然科学基金;

关键词：

RECEPTOR AGONIST TIRZEPATIDE; CELL-DEATH; NONALCOHOLIC STEATOHEPATITIS; SIGNALING PATHWAY; DUAL GIP; FIBROSIS; FERROPTOSIS; INJURY; ACTIVATION; METABOLISM;

D O I：

10.1016/j.molmed.2023.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The liver can succumb to oxidant damage during the development of chronic liver diseases. Despite their physiological relevance to hepatic homeostasis, excessive reactive oxygen/nitrogen species (ROS/RNS) production under pathological con-ditions is detrimental to all liver constituents. Chronic oxidative stress coupled to unresolved inflammation sets in motion the activation of profibrogenic hepatic stellate cells (HSCs) and later pathogenesis of liver fibrosis, cirrhosis, and liver cancer. The liver antioxidant and repair systems, along with autophagic and ferroptotic machineries, are implicated in the onset and trajectory of disease development. In this review, we discuss the ROS/RNS-related mechanisms underlying liver fibrosis of distinct etiologies and highlight preclinical and clinical trials of antifibrotic therapies premised on remediating oxidative/nitrosative stress in hepatocytes or targeting HSC activation.

引用

页码：951 / 967

页数：17

共 119 条

[1] Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B [J].

Acerbi, Greta ;

Montali, Ilaria ;

Ferrigno, Gennaro Domenico ;

Barili, Valeria ;

Schivazappa, Simona ;

Alfieri, Arianna ;

Laccabue, Diletta ;

Loglio, Alessandro ;

Borghi, Marta ;

Massari, Marco ;

Rossi, Marzia ;

Vecchi, Andrea ;

Penna, Amalia ;

Boni, Carolina ;

Missale, Gabriele ;

Lampertico, Pietro ;

Del Rio, Daniele ;

Ferrari, Carlo ;

Fisicaro, Paola .

JOURNAL OF HEPATOLOGY, 2021, 74 (04) :783-793

[2] Selective activation of PFKL suppresses the phagocytic oxidative burst [J].

Amara, Neri ;

Cooper, Madison P. ;

Voronkova, Maria A. ;

Webb, Bradley A. ;

Lynch, Eric M. ;

Kollman, Justin M. ;

Ma, Taylur ;

Yu, Kebing ;

Lai, Zijuan ;

Sangaraju, Dewakar ;

Kayagaki, Nobuhiko ;

Newton, Kim ;

Bogyo, Matthew ;

Staben, Steven T. ;

Dixit, Vishva M. .

CELL, 2021, 184 (17) :4480-+

[3] Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications [J].

Apostolova, Nadezda ;

Victor, Victor M. .

ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (08) :686-729

[4] Burden of liver diseases in the world [J].

Asrani, Sumeet K. ;

Devarbhavi, Harshad ;

Eaton, John ;

Kamath, Patrick S. .

JOURNAL OF HEPATOLOGY, 2019, 70 (01) :151-171

[5] Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial [J].

Bril, Fernando ;

Biernacki, Diane M. ;

Kalavalapalli, Srilaxmi ;

Lomonaco, Romina ;

Subbarayan, Sreevidya K. ;

Lai, Jinping ;

Tio, Fermin ;

Suman, Amitabh ;

Orsak, Beverly K. ;

Hecht, Joan ;

Cusi, Kenneth .

DIABETES CARE, 2019, 42 (08) :1481-1488

[6] Hydronidone for the Treatment of Liver Fibrosis Related to Chronic Hepatitis B: A Phase 2 Randomized Controlled Trial [J].

Cai, Xiaobo ;

Liu, Xuehan ;

Xie, Wen ;

Ma, Anlin ;

Tan, Youwen ;

Shang, Jia ;

Zhang, Jiming ;

Chen, Chengwei ;

Yu, Yanyan ;

Qu, Ying ;

Zhang, Ling ;

Luo, Ying ;

Yin, Ping ;

Cheng, Jun ;

Lu, Lungen .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2023, 21 (07) :1893-1901

[7] Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver [J].

Cappel, David A. ;

Deja, Stanislaw ;

Duarte, Joao A. G. ;

Kucejova, Blanka ;

Inigo, Melissa ;

Fletcher, Justin A. ;

Fu, Xiaorong ;

Berglund, Eric D. ;

Liu, Tiemin ;

Elmquist, Joel K. ;

Hammer, Suntrea ;

Mishra, Prashant ;

Browning, Jeffrey D. ;

Burgess, Shawn C. .

CELL METABOLISM, 2019, 29 (06) :1291-+

[8] Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice [J].

Chen, Shuai ;

Lu, Zhi ;

Jia, Haoyu ;

Yang, Bo ;

Liu, Chun ;

Yang, Yuxin ;

Zhang, Shuo ;

Wang, Zhijing ;

Yang, Liu ;

Li, Shanshan ;

Li, Jing ;

Yang, Changqing .

JOURNAL OF HEPATOLOGY, 2023, 78 (03) :543-557

[9] Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway [J].

Chiu, David Kung-Chun ;

Tse, Aki Pui-Wah ;

Law, Cheuk-Ting ;

Xu, Iris Ming-Jing ;

Lee, Derek ;

Chen, Mengnuo ;

Lai, Robin Kit-Ho ;

Yuen, Vincent Wai-Hin ;

Cheu, Jacinth Wing-Sum ;

Ho, Daniel Wai-Hung ;

Wong, Chun-Ming ;

Zhang, Huafeng ;

Ng, Irene Oi-Lin ;

Wong, Carmen Chak-Lui .

CELL DEATH & DISEASE, 2019, 10 (12)

[10] Inducible nitric oxide synthase: Regulation, structure, and inhibition [J].

Cinelli, Maris A. ;

Do, Ha T. ;

Miley, Galen P. ;

Silverman, Richard B. .

MEDICINAL RESEARCH REVIEWS, 2020, 40 (01) :158-189

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