Prodromal dementia with Lewy bodies in REM sleep behavior disorder: A multicenter study

被引：15

作者：

Joza, Stephen ^{[1
]}

Hu, Michele T. ^{[2
,3
]}

Jung, Ki-Young ^{[4
]}

Kunz, Dieter ^{[5
]}

Arnaldi, Dario ^{[6
,7
]}

Lee, Jee-Young ^{[8
]}

Ferini-Strambi, Luigi ^{[9
]}

Antelmi, Elena ^{[10
]}

Sixel-Doering, Friederike ^{[11
,12
,13
]}

De Cock, Valerie Cochen ^{[14
,15
]}

Montplaisir, Jacques Y. ^{[16
,17
]}

Welch, Jessica ^{[2
,3
]}

Kim, Han-Joon ^{[4
]}

Bes, Frederik ^{[5
]}

Mattioli, Pietro ^{[6
]}

Woo, Kyung Ah ^{[8
]}

Marelli, Sara ^{[9
]}

Plazzi, Giuseppe ^{[18
,19
]}

Mollenhauer, Brit ^{[11
,12
,13
]}

Pelletier, Amelie ^{[1
,16
]}

Razzaque, Jamil ^{[2
,3
]}

Sunwoo, Jun-Sang ^{[20
]}

Girtler, Nicola ^{[6
,7
]}

Trenkwalder, Claudia ^{[13
,21
]}

Gagnon, Jean-Francois ^{[16
,17
]}

Postuma, Ronald B. ^{[1
]}

机构：

[1] Montreal Neurol Inst, Dept Neurol, Montreal, PQ, Canada

[2] Univ Oxford, Div Neurol, Nuffield Dept Clin Neurosci, Oxford, England

[3] Univ Oxford, Oxford Parkinsons Dis Ctr, Oxford, England

[4] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea

[5] St Hedwig Krankenhaus, Clin Sleep & Chronomed, Berlin, Germany

[6] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Clin Neurol, Genoa, Italy

[7] IRCCS Osped Policlin San Martino, Genoa, Italy

[8] Seoul Natl Univ, Seoul Metropolitan Govt Seoul Natl Univ BoramaeMe, Dept Neurol, Coll Med, Seoul, South Korea

[9] Univ Vita Salute San Raffaele, Sleep Disorders Ctr, Milan, Italy

[10] Univ Verona, DIMI Dept Engn & Med Innovat, Verona, Italy

[11] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[12] Philipps Univ Marburg, Sect Clin Neurosci, Marburg, Germany

[13] Paracelsus Elena Klin, Ctr Movement Disorders, Kassel, Germany

[14] Univ Montpellier, EuroMov Digital Hlth Mot, IMT Mines Ales, Montpellier, France

[15] Beau Soleil Clin, Dept Neurol & Sleep, Montpellier, France

[16] Hop Sacre Coeur Montreal, Ctr Etudes Avancees Med Sommeil, Montreal, PQ, Canada

[17] Univ Quebec aMontreal, Dept Psychol, Montreal, PQ, Canada

[18] IRCCS Ist Sci Neurol Bologna, Bologna, Italy

[19] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy

[20] Kangbuk Samsung Hosp, Dept Neurol, Seoul, South Korea

[21] Univ Med Ctr Goettingen, Dept Neurosurg, Gottingen, Germany

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 01期

基金：

加拿大健康研究院; 新加坡国家研究基金会;

关键词：

dementia with Lewy bodies; evolution; Parkinson's disease; pre-diagnostic; prodromal stage; REM sleep behavior disorder; MILD COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; CRITERIA;

D O I：

10.1002/alz.13386

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionIsolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) is a powerful early predictor of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). This provides an opportunity to directly observe the evolution of prodromal DLB and to identify which cognitive variables are the strongest predictors of evolving dementia. MethodsIRBD participants (n = 754) from 10 centers of the International RBD Study Group underwent annual neuropsychological assessment. Competing risk regression analysis determined optimal predictors of dementia. Linear mixed-effect models determined the annual progression of neuropsychological testing. ResultsReduced attention and executive function, particularly performance on the Trail Making Test Part B, were the strongest identifiers of early DLB. In phenoconverters, the onset of cognitive decline began up to 10 years prior to phenoconversion. Changes in verbal memory best differentiated between DLB and PD subtypes. DiscussionIn iRBD, attention and executive dysfunction strongly predict dementia and begin declining several years prior to phenoconversion.

引用

页码：91 / 102

页数：12

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