Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2

被引：185

作者：

Qu, Panke ^{[1
,2
]}

Evans, John P. ^{[1
,2
,3
]}

Faraone, Julia N. ^{[1
,2
,3
]}

Zheng, Yi-Min ^{[1
,2
]}

Carlin, Claire ^{[4
]}

Anghelina, Mirela ^{[5
]}

Stevens, Patrick ^{[5
]}

Fernandez, Soledad ^{[5
]}

Jones, Daniel ^{[6
]}

Lozanski, Gerard ^{[6
]}

Panchal, Ashish ^{[7
]}

Saif, Linda J. ^{[8
,9
,10
]}

Oltz, Eugene M. ^{[11
]}

Xu, Kai ^{[1
,2
]}

Gumina, Richard J. ^{[4
,12
,13
]}

Liu, Shan-Lu ^{[1
,2
,10
,11
]}

机构：

[1] Ohio State Univ, Ctr Retrovirus Res, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA

[3] Ohio State Univ, Mol Cellular & Dev Biol Program, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Internal Med, Div Cardiovasc Med, Columbus, OH 43210 USA

[5] Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA

[6] Ohio State Univ, Dept Pathol, Wexner Med Ctr, Columbus, OH USA

[7] Ohio State Univ, Dept Emergency Med, Wexner Med Ctr, Columbus, OH USA

[8] Ohio State Univ, Coll Food Agr & Environm Sci, Ctr Food Anim Hlth, Anim Sci Dept,OARDC, Wooster, OH 44691 USA

[9] Ohio State Univ, Coll Vet Med, Vet Prevent Med Dept, Wooster, OH 44691 USA

[10] Ohio State Univ, Infect Dis Inst, Viruses & Emerging Pathogens Program, Columbus, OH 43210 USA

[11] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH 43210 USA

[12] Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Wexner Med Ctr, Columbus, OH 43210 USA

[13] Ohio State Univ, Coll Med, Dept Physiol & Cell Biol, Wexner Med Ctr, Columbus, OH 43210 USA

来源：

CELL HOST & MICROBE | 2023年 / 31卷 / 01期

关键词：

immune evasion; molecular modeling; mutations; neutralization; Omicron subvariants;

D O I：

10.1016/j.chom.2022.11.012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The continued evolution of SARS-CoV-2 has led to the emergence of several new Omicron subvariants, including BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2. Here, we examine the neutralization resistance of these subvariants against sera from 3-dose vaccinated healthcare workers, hospitalized BA.1-wave patients, and BA.4/5-wave patients. We found enhanced neutralization resistance in all new subvariants, especially in the BQ.1 and BQ.1.1 subvariants driven by N460K and K444T mutations, as well as the BA.2.75.2 subvariant driven largely by its F486S mutation. All Omicron subvariants maintained their weakened infectivity in Calu-3 cells, with the F486S mutation driving further diminished titer for the BA.2.75.2 subvariant. Molecular modeling revealed the mechanisms of antibody-mediated immune evasion by R346T, K444T, F486S, and D1199N mutations. Altogether, these findings shed light on the evolution of newly emerging SARS-CoV-2 Omicron subvariants.

引用

页码：9 / +

页数：13

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