Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer

被引：0
作者：
Kovaleva, O. V. [1 ]
Podlesnaya, P. A. [1 ]
Mochalnikova, V. V. [1 ]
Kushlinskii, N. E. [1 ]
Gratchev, A. N. [1 ]
机构：
[1] Minist Hlth Russian Federat, NN Blokhin Natl Med Res Ctr Oncol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 174卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
lung cancer; neutrophil; CD66b; prognosis; INTRATUMORAL NEUTROPHILS;
D O I：
10.1007/s10517-023-05797-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the expression of CD66b (a protein of the cancer-embryonic antigen family, expressed mainly in neutrophils) in tumor and stromal cells of non-small cell lung cancer (93 samples). The number of CD66b(+) neutrophils is not associated with clinical and morphological parameters of the tumors and the disease prognosis. However, CD66b is expressed in the tumor cells of most studied samples. CD66b expression is also associated with the histological type of tumor and its localization. Increased expression of CD66b in tumor cells indicated a more favorable prognosis, which allows using this protein as a prognostic marker and as a potential target for the immunotherapy.
引用
收藏
页码：779 / 783
页数：5
相关论文
共 13 条
[1]   Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy [J].
Albini, Adriana ;
Bruno, Antonino ;
Noonan, Douglas M. ;
Mortara, Lorenzo .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[2]   Tumor-associated neutrophils and macrophages in non-small cell lung cancer: No immediate impact on patient outcome [J].
Carus, Andreas ;
Ladekarl, Morten ;
Hager, Henrik ;
Pilegaard, Hans ;
Nielsen, Patricia S. ;
Donskov, Frede .
LUNG CANCER, 2013, 81 (01) :130-137
[3]   Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy [J].
Caruso, RA ;
Bellocco, R ;
Pagano, M ;
Bertoli, G ;
Rigoli, L ;
Inferrera, C .
MODERN PATHOLOGY, 2002, 15 (08) :831-837
[4]   Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive T-cell ratio in patients with resectable nonsmall cell lung cancer [J].
Ilie, Marius ;
Hofman, Veronique ;
Ortholan, Cecile ;
Bonnetaud, Christelle ;
Coelle, Celine ;
Mouroux, Jerome ;
Hofman, Paul .
CANCER, 2012, 118 (06) :1726-1737
[5]   Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma [J].
Jensen, Trine O. ;
Schmidt, Henrik ;
Moller, Holger J. ;
Donskov, Frede ;
Hoyer, Morten ;
Sjoegren, Pia ;
Christensen, Ib J. ;
Steiniche, Torben .
CANCER, 2012, 118 (09) :2476-2485
[6]   Neutrophils dominate the immune cell composition in non-small cell lung cancer [J].
Kargl, Julia ;
Busch, Stephanie E. ;
Yang, Grace H. Y. ;
Kim, Kyoung-Hee ;
Hanke, Mark L. ;
Metz, Heather E. ;
Hubbard, Jesse J. ;
Lee, Sylvia M. ;
Madtes, David K. ;
McIntosh, Martin W. ;
Houghton, A. McGarry .
NATURE COMMUNICATIONS, 2017, 8
[7]   Lung Microbiome Differentially Impacts Survival of Patients with Non-Small Cell Lung Cancer Depending on Tumor Stroma Phenotype [J].
Kovaleva, Olga ;
Podlesnaya, Polina ;
Rashidova, Madina ;
Samoilova, Daria ;
Petrenko, Anatoly ;
Zborovskaya, Irina ;
Mochalnikova, Valeria ;
Kataev, Vladimir ;
Khlopko, Yuri ;
Plotnikov, Andrey ;
Gratchev, Alexei .
BIOMEDICINES, 2020, 8 (09)
[8]   CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer [J].
Kovaleva, Olga V. ;
Rashidova, Madina A. ;
Samoilova, Daria V. ;
Podlesnaya, Polina A. ;
Tabiev, Rasul M. ;
Mochalnikova, Valeria V. ;
Gratchev, Alexei .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (01) :1-16
[9]   On the dual roles and polarized phenotypes of neutrophils in tumor development and progression [J].
Piccard, H. ;
Muschel, R. J. ;
Opdenakker, G. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2012, 82 (03) :296-309
[10]   Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer [J].
Rakaee, Mehrdad ;
Busund, Lill-Tove ;
Paulsen, Erna-Elise ;
Richardsen, Elin ;
Al-Saad, Samer ;
Andersen, Sigve ;
Donnem, Tom ;
Bremnes, Roy M. ;
Kilvaer, Thomas K. .
ONCOTARGET, 2016, 7 (44) :72184-72196
12