Application of Low-Frequency Raman Spectroscopy to Probe Dynamics of Lipid Mesophase Transformations upon Hydration

被引：3

作者：

Krog, Lasse S. ^{[1
]}

Kirkensgaard, Jacob J. K. ^{[2
,3
]}

Fodera, Vito ^{[1
]}

Boyd, Ben J. ^{[1
,4
]}

Berzins, Karlis ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Fac Sci, Dept Food Sci, DK-1958 Frederiksberg C, Denmark

[3] Univ Copenhagen, Niels Bohr Inst, Fac Sci, DK-2100 Copenhagen, Denmark

[4] Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic 3052, Australia

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2023年 / 127卷 / 14期

关键词：

X-RAY-DIFFRACTION; SCATTERING SPECTROSCOPY; DRUG SOLUBILIZATION; PHASE; MILK;

D O I：

10.1021/acs.jpcb.2c08150

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Low-frequency Raman (LFR) spectroscopy is presented as a viable tool for studying the hydration characteristics of lyotropic liquid crystal systems herein. Monoolein was used as a model compound, and its structural changes were probed both in sit u and ex sit u which enabled a comparison between different hydration states. A custom-built instrumental configuration allowed the advantages of LFR spectroscopy to be utilized for dynamic hydration analysis. On the other hand, static measurements of with varied showcased the structural sensiti v i t y of LFR spectroscopy. The subtle differences not intuitively observed between similar self-assembled architectures were distinguished by chemometric analysis that directly correlated with the results from small-angle X-ray scattering (SAXS), which is the current "gold standard" method for determi n i n g the structure of such materials.

引用

页码：3223 / 3230

页数：8

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