BAG3: Nature's Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue

被引：10

作者：

Brenner, Caitlyn M. ^{[1
]}

Choudhary, Muaaz ^{[1
]}

McCormick, Michael G. ^{[1
,2
]}

Cheung, David ^{[1
,2
]}

Landesberg, Gavin P. ^{[1
,2
]}

Wang, Ju-Fang ^{[1
,2
]}

Song, Jianliang ^{[1
,2
]}

Martin, Thomas G. ^{[3
]}

Cheung, Joseph Y. ^{[4
]}

Qu, Hui-Qi ^{[5
]}

Hakonarson, Hakon ^{[5
,6
,7
,8
,9
,10
,11
]}

Feldman, Arthur M. ^{[1
,2
]}

机构：

[1] Temple Univ, Dept Med, Div Cardiol, Lewis Katz Sch Med, 3500 N Broad St,MERB 752, Philadelphia, PA 19140 USA

[2] Temple Univ, Ctr Neurovirol & Gene Editing, Lewis Katz Sch Med, Philadelphia, PA 19140 USA

[3] Colorado Univ, Dept Mol Cellular & Dev Biol, Sch Med, Aurora, CO 80045 USA

[4] Harvard Med Sch, Brigham & Womens Hosp, Div Renal Med, Boston, MA 02115 USA

[5] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA USA

[6] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA USA

[7] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA USA

[8] Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA USA

[9] Univ Penn, Perelman Sch Med, Dept Pediat, Div Human Genet, Philadelphia, PA USA

[10] Univ Penn, Perelman Sch Med, Div Pulm Med, Philadelphia, PA USA

[11] Univ Penn, Perelman Sch Med, Div Pulm Med, Philadelphia, PA USA

来源：

CELLS | 2023年 / 12卷 / 06期

关键词：

BAG3; heart; autophagy; apoptosis; excitation contraction coupling; mitochondria; cellular inhibitor of activation protein cIAP; mitochondrial uniporter; CO-CHAPERONE BAG3; CELL-DEATH; DILATED CARDIOMYOPATHY; SELECTIVE AUTOPHAGY; BCL-2-BINDING PROTEIN; MITOCHONDRIAL CA2+; STRESS; EXPRESSION; APOPTOSIS; CANCER;

D O I：

10.3390/cells12060937

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many cancers. We describe BAG3 as a quintessential multi-functional protein. It supports autophagy of both misfolded proteins and damaged organelles, inhibits apoptosis, maintains the homeostasis of the mitochondria, and facilitates excitation contraction coupling through the L-type calcium channel and the beta-adrenergic receptor. High levels of BAG3 are associated with insensitivity to chemotherapy in malignant cells whereas both loss of function and gain of function variants are associated with cardiomyopathy.

引用

页数：23