Impact of elderly gastrointestinal alterations on gastric emptying and enzymatic hydrolysis of skim milk: An in vitro study using a dynamic stomach system

被引:19
作者
Zhang, Ping [1 ]
Iqbal, Shahid [1 ]
Deng, Renpan [2 ]
Duan, Xu [3 ]
Han, Huaxin [4 ]
Chen, Xiao Dong [1 ]
Wu, Peng [1 ]
机构
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Sch Chem & Environm Engn, Life Qual Interest Grp, Suzhou 215123, Jiangsu, Peoples R China
[2] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832000, Peoples R China
[3] Henan Univ Sci & Technol, Coll Food & Bioengn, Luoyang 471023, Henan, Peoples R China
[4] Zhenjiang Inst Agr Sci Hilly Reg Jiangsu Prov, Jurong 212400, Peoples R China
基金
中国国家自然科学基金;
关键词
Skim milk; Elderly; Gastric emptying; Microstructure; In vitro digestion; Protein hydrolysis; DIGESTION MODELS; HEALTHY; FOOD; ABSORPTION; LIQUID; AGE;
D O I
10.1016/j.foodchem.2022.134365
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
This study aimed to evaluate gastric emptying and enzymatic hydrolysis of skim milk using a dynamic in vitro gastrointestinal system mimicking digestive conditions in young adult and elderly individuals. The gastric emptying half-time was 22.5 and 26.5 min in the young adult and elderly models, respectively. The degree of proteolysis at 120 min reached 42.3 % under adult digestion, significantly higher than that for the elderly (37.2 %). Moreover, milk proteins, particularly beta-lactoglobulin, was more resistant to hydrolysis throughout elderly digestion. The slowed gastric emptying and impaired proteolysis were supported by the formation of more large clusters and protein aggregates under elderly digestion particularly between 60 and 120 min. This was attributed to the decreased gastric contractions and lowered digestive secretions in the elderly model that would impede the flow and breakdown of protein aggregates. This study is meaningful for future development of milk products that are more suitable for the elderly.
引用
收藏
页数:9
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