Absence of Hypercoagulation Status after Neoadjuvant Treatment is Associated with Favorable Prognosis in Patients Undergoing Subtotal Esophagectomy for Esophageal Squamous Cell Carcinoma

被引:2
作者
Sugiyama, Fumitake [1 ]
Kanda, Mitsuro [1 ]
Shimizu, Dai [1 ]
Umeda, Shinichi [1 ]
Inokawa, Yoshikuni [1 ]
Hattori, Norifumi [1 ]
Hayashi, Masamichi [1 ]
Tanaka, Chie [1 ]
Nakayama, Goro [1 ]
Kodera, Yasuhiro [1 ]
机构
[1] Nagoya Univ, Dept Surg Gastroenterol, Grad Sch Med, Nagoya, Aichi, Japan
关键词
PREDICTIVE MARKER; LYMPHOCYTE RATIO; PHASE-III; CANCER; PLATELET; ASPIRIN; METASTASIS; RECURRENCE; SURVIVAL; THERAPY;
D O I
10.1245/s10434-024-14938-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. Abnormal activation of the coagulation system is associated with malignant tumor progression. Although neoadjuvant treatment (NAT) for resectable esophageal squamous cell carcinoma (ESCC) is the standard of care, the correlation between coagulation status and prognosis of patients undergoing preoperative treatment is insufficiently understood. Methods. Patients (n = 200) who underwent radical subtotal esophagectomy after preoperative treatment for ESCC between January 2012 and December 2021were included in the analysis. Plasma D-dimer and fibrinogen levels and their combined indices (non-hypercoagulation; D-dimer and fibrinogen levels within the upper normal limit, or hypercoagulation; D-dimer or fibrinogen levels above the upper normal limit) were determined before and after NAT and correlated to clinicopathological factors and prognosis. Results. The nonhypercoagulation group achieved superior overall survival (OS) than the hypercoagulation group (5-year OS rates = 89% vs. 55%; hazard ratio 3.62, P = 0.0008) when determined according to coagulation status after NAT. Multivariate analysis showed that hypercoagulation after NAT served as an independent factor for poor postoperative OS (hazard ratio 3.20; P = 0.0028). The nonhypercoagulation group achieved significantly better disease-free survival (76% vs. 54%; P = 0.0065) than the hypercoagulation group that experienced a significantly higher rate of hematogenous metastasis as an initial recurrence (P = 0.0337). Conclusions. Hypercoagulation state after NAT served as a valid indicator correlating with postoperative outcomes of patients with ESCC who underwent NAT followed by radical subtotal esophagectomy.
引用
收藏
页码:3417 / 3425
页数:9
相关论文
共 44 条
[1]   A Randomized Trial Comparing Postoperative Adjuvant Chemotherapy with Cisplatin and 5-Fluorouracil Versus Preoperative Chemotherapy for Localized Advanced Squamous Cell Carcinoma of the Thoracic Esophagus (JCOG9907) [J].
Ando, Nobutoshi ;
Kato, Hoichi ;
Igaki, Hiroyasu ;
Shinoda, Masayuki ;
Ozawa, Soji ;
Shimizu, Hideaki ;
Nakamura, Tsutomu ;
Yabusaki, Hiroshi ;
Aoyama, Norio ;
Kurita, Akira ;
Ikeda, Kenichiro ;
Kanda, Tatsuo ;
Tsujinaka, Toshimasa ;
Nakamura, Kenichi ;
Fukuda, Haruhiko .
ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (01) :68-74
[2]  
[Anonymous], 2020, CA Cancer J Clin, V70, P313, DOI [10.3322/caac.21492, 10.3322/caac.21609]
[3]   Protective association of aspirin/NSAIDs and esophageal cancer: A systematic review and meta-analysis [J].
Corley, DA ;
Kerlikowske, K ;
Verma, R ;
Buffler, P .
GASTROENTEROLOGY, 2003, 124 (01) :47-56
[4]   ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours [J].
Coyle, Christopher ;
Cafferty, Fay H. ;
Rowley, Samuel ;
MacKenzie, Mairead ;
Berkman, Lindy ;
Gupta, Sudeep ;
Pramesh, C. S. ;
Gilbert, Duncan ;
Kynaston, Howard ;
Cameron, David ;
Wilson, Richard H. ;
Ring, Alistair ;
Langley, Ruth E. .
CONTEMPORARY CLINICAL TRIALS, 2016, 51 :56-64
[5]   Prognostic value of the D-dimer test in oesophageal cancer during the perioperative period [J].
Diao, Dongmei ;
Zhu, Kun ;
Wang, Zhe ;
Cheng, Yao ;
Li, Kang ;
Pei, Leilei ;
Dang, Chengxue .
JOURNAL OF SURGICAL ONCOLOGY, 2013, 108 (01) :34-41
[6]   Coagulation and cancer: biological and clinical aspects [J].
Falanga, A. ;
Marchetti, M. ;
Vignoli, A. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (02) :223-233
[7]   Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma [J].
Feng, Ji-Feng ;
Huang, Ying ;
Chen, Qi-Xun .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2014, 12
[8]   Cancer-associated thrombosis: the when, how and why [J].
Fernandes, Caio J., Jr. ;
Morinaga, Luciana T. K. ;
Alves, Jose L. ;
Castro, Marcela A. ;
Calderaro, Daniela ;
Jardim, Carlos V. P. ;
Souza, Rogerio .
EUROPEAN RESPIRATORY REVIEW, 2019, 28 (151)
[9]   Contribution of platelets to tumour metastasis [J].
Gay, Laurie J. ;
Felding-Habermann, Brunhilde .
NATURE REVIEWS CANCER, 2011, 11 (02) :123-134
[10]   Association between the use of aspirin and risk of lung cancer: results from pooled cohorts and Mendelian randomization analyses [J].
Jiang, Yu ;
Su, Zixuan ;
Li, Caichen ;
Wang, Runchen ;
Wen, Yaokai ;
Liang, Hengrui ;
He, Jianxing ;
Liang, Wenhua .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2021, 147 (01) :139-151