A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases

被引：242

作者：

Barnett, Katherine C. ^{[1
,2
,3
]}

Li, Sirui ^{[1
,2
,3
]}

Liang, Kaixin ^{[1
,2
,3
,4
]}

Ting, Jenny P. -Y. ^{[1
,2
,3
,4
]}

机构：

[1] Univ North Carolina Chapel Hill, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ North Carolina Chapel Hill, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[4] Univ North Carolina Chapel Hill, Adams Sch Dent, Oral & Craniofacial Biomed Program, Chapel Hill, NC 27599 USA

来源：

CELL | 2023年 / 186卷 / 11期

关键词：

NF-KAPPA-B; MEDITERRANEAN FEVER PROTEIN; ANTHRAX LETHAL TOXIN; DNA SENSOR AIM2; NLRP3; INFLAMMASOME; GASDERMIN-D; PYRIN INFLAMMASOME; INTESTINAL HOMEOSTASIS; IMMUNE RECOGNITION; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.cell.2023.04.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammasomes are critical sentinels of the innate immune system that respond to threats to the host through recognition of distinct molecules, known as pathogen-or damage-associated molecular patterns (PAMPs/ DAMPs), or disruptions of cellular homeostasis, referred to as homeostasis-altering molecular processes (HAMPs) or effector-triggered immunity (ETI). Several distinct proteins nucleate inflammasomes, including NLRP1, CARD8, NLRP3, NLRP6, NLRC4/NAIP, AIM2, pyrin, and caspases-4/-5/-11. This diverse array of sen-sors strengthens the inflammasome response through redundancy and plasticity. Here, we present an over-view of these pathways, outlining the mechanisms of inflammasome formation, subcellular regulation, and pyroptosis, and discuss the wide-reaching effects of inflammasomes in human disease.

引用

页码：2288 / 2312

页数：25

共 300 条

[1] Caspase-11 Protects Against Bacteria That Escape the Vacuole [J].

Aachoui, Youssef ;

Leaf, Irina A. ;

Hagar, Jon A. ;

Fontana, Mary F. ;

Campos, Cristine G. ;

Zak, Daniel E. ;

Tan, Michael H. ;

Cotter, Peggy A. ;

Vance, Russell E. ;

Aderem, Alan ;

Miao, Edward A. .

SCIENCE, 2013, 339 (6122) :975-978

[2] Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease [J].

Abbate, Antonio ;

Toldo, Stefano ;

Marchetti, Carlo ;

Kron, Jordana ;

Van Tassell, Benjamin W. ;

Dinarello, Charles A. .

CIRCULATION RESEARCH, 2020, 126 (09) :1260-1280

[3] GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].

Aglietti, Robin A. ;

Estevez, Alberto ;

Gupta, Aaron ;

Ramirez, Monica Gonzalez ;

Liu, Peter S. ;

Kayagaki, Nobuhiko ;

Ciferri, Claudio ;

Dixit, Vishva M. ;

Dueber, Erin C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863

[4] Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization [J].

Akhter, Anwari ;

Caution, Kyle ;

Abu Khweek, Arwa ;

Tazi, Mia ;

Abdulrahman, Basant A. ;

Abdelaziz, Dalia H. A. ;

Voss, Oliver H. ;

Doseff, Andrea I. ;

Hassan, Hoda ;

Azad, Abul K. ;

Schlesinger, Larry S. ;

Wewers, Mark D. ;

Gavrilin, Mikhail A. ;

Amer, Amal O. .

IMMUNITY, 2012, 37 (01) :35-47

[5]

Aksentijevich I, 1997, CELL, V90, P797

[6] Familial Mediterranean fever, review of the literature [J].

Alghamdi, Mansour .

CLINICAL RHEUMATOLOGY, 2017, 36 (08) :1707-1713

[7] The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer [J].

Allen, Irving C. ;

TeKippe, Erin McElvania ;

Woodford, Rita-Marie T. ;

Uronis, Joshua M. ;

Holl, Eda K. ;

Rogers, Arlin B. ;

Herfarth, Hans H. ;

Jobin, Christian ;

Ting, Jenny P. -Y. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (05) :1045-1056

[8] The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA [J].

Allen, Irving C. ;

Scull, Margaret A. ;

Moore, Chris B. ;

Holl, Eda K. ;

McElvania-TeKippe, Erin ;

Taxman, Debra J. ;

Guthrie, Elizabeth H. ;

Pickles, Raymond J. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2009, 30 (04) :556-565

[9] Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf [J].

Amer, Amal ;

Franchi, Luigi ;

Kanneganti, Thirumala-Devi ;

Body-Malapel, Mathilde ;

Ozoren, Nesrin ;

Brady, Graham ;

Meshinchi, Sasha ;

Jagirdar, Rajesh ;

Gewirtz, Andrew ;

Akira, Shizuo ;

Nunez, Gabriel .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (46) :35217-35223

[10] NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens [J].

Anand, Paras K. ;

Malireddi, R. K. Subbarao ;

Lukens, John R. ;

Vogel, Peter ;

Bertin, John ;

Lamkanfi, Mohamed ;

Kanneganti, Thirumala-Devi .

NATURE, 2012, 488 (7411) :389-+

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