Role of Oxygen Starvation in Right Ventricular Decompensation and Failure in Pulmonary Arterial Hypertension

被引：6

作者：

Okninska, Marta ^{[1
]}

Zajda, Karolina ^{[2
]}

Zambrowska, Zuzanna ^{[1
]}

Grzanka, Malgorzata ^{[3
]}

Paterek, Aleksandra ^{[1
]}

Mackiewicz, Urszula ^{[1
]}

Szczylik, Cezary ^{[4
]}

Kurzyna, Marcin ^{[5
]}

Piekielko-Witkowska, Agnieszka ^{[3
]}

Torbicki, Adam ^{[5
]}

Kieda, Claudine ^{[2
,6
,7
]}

Maczewski, Michal ^{[1
]}

机构：

[1] Ctr Postgrad Med Educ, Dept Clin Physiol, Marymoncka Str 99-103, PL-01813 Warsaw, Poland

[2] Mil Med Inst, Lab Mol Oncol & Innovat Therapies, Warsaw, Poland

[3] Ctr Postgrad Med Educ, Dept Biochem & Mol Biol, Warsaw, Poland

[4] Ctr Postgrad Med Educ, Dept Oncol ECZ Otwock, Warsaw, Poland

[5] Ctr Postgrad Med Educ, Dept Pulm Circulat Thromboembol Dis & Cardiol ECZ, Warsaw, Poland

[6] Ctr Mol Biophys, UPR, CNRS 4301, Orleans, France

[7] Ctr Postgrad Med Educ, Dept Mol & Translat Oncol, Warsaw, Poland

来源：

JACC-HEART FAILURE | 2024年 / 12卷 / 02期

关键词：

angiogenesis; hypertrophy; oxygen deficiency; pulmonary arterial hypertension; right ventricular failure;

D O I：

10.1016/j.jchf.2023.03.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Right ventricular (RV) function and eventually failure determine outcome in patients with pulmonary arterial hypertension (PAH). Initially, RV responds to an increased load caused by PAH with adaptive hypertrophy; however, eventually RV failure ensues. Unfortunately, it is unclear what causes the transition from compensated RV hypertrophy to decompensated RV failure. Moreover, at present, there are no therapies for RV failure; those for left ventricular (LV) failure are ineffective, and no therapies specifically targeting RV are available. Thus there is a clear need for understanding the biology of RV failure and differences in physiology and pathophysiology between RV and LV that can ultimately lead to development of such therapies. In this paper, we discuss RV adaptation and maladaptation in PAH, with a particular focus of oxygen delivery and hypoxia as the principal drivers of RV hypertrophy and failure, and attempt to pinpoint potential sites for therapy. (J Am Coll Cardiol HF 2024;12:235-247) (c) 2024 by the American College of Cardiology Foundation.

引用

页码：235 / 247

页数：13

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