Approach to the Patient With Hypothalamic Obesity

被引：8

作者：

Shoemaker, Ashley H. ^{[1
]}

Tamaroff, Jaclyn ^{[1
]}

机构：

[1] Vanderbilt Univ, Pediat Endocrinol, Med Ctr, 1500 21st Ave S,Ste 1514, Nashville, TN 37212 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 108卷 / 05期

基金：

美国国家卫生研究院;

关键词：

hypothalamic obesity; craniopharyngioma; obesity; CHILDHOOD CRANIOPHARYNGIOMA; BARIATRIC SURGERY; CONTROLLED-TRIAL; RISK-FACTORS; DOUBLE-BLIND; BODY-WEIGHT; CHILDREN; SAFETY; SURVIVORS; THERAPY;

D O I：

10.1210/clinem/dgac678

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypothalamic obesity (HO) is defined as abnormal weight gain due to physical destruction of the hypothalamus. Suprasellar tumors, most commonly craniopharyngiomas, are a classic cause of HO. HO often goes unnoticed initially as patients, families, and medical teams are focused on oncologic treatments and management of panhypopituitarism. HO is characterized by rapid weight gain in the first year after hypothalamic destruction followed by refractory obesity due to an energy imbalance of decreased energy expenditure without decreased food intake. Currently available pharmacotherapies are less effective in HO than in common obesity. While not a cure, dietary interventions, pharmacotherapy, and bariatric surgery can mitigate the effects of HO. Early recognition of HO is necessary to give an opportunity to intervene before substantial weight gain occurs. Our goal for this article is to review the pathophysiology of HO and to discuss available treatment options and future directions for prevention and treatment.

引用

页码：1236 / 1242

页数：7

共 71 条

[1] Hypothalamic Obesity: Prologue and Promise [J].

Abuzzahab, M. Jennifer ;

Roth, Christian L. ;

Shoemaker, Ashley H. .

HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 (02) :128-136

[2] GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults [J].

Allen, D. B. ;

Backeljauw, P. ;

Bidlingmaier, M. ;

Biller, B. M. K. ;

Boguszewski, M. ;

Burman, P. ;

Butler, G. ;

Chihara, K. ;

Christiansen, J. ;

Cianfarani, S. ;

Clayton, P. ;

Clemmons, D. ;

Cohen, P. ;

Darendeliler, F. ;

Deal, C. ;

Dunger, D. ;

Erfurth, E. M. ;

Fuqua, J. S. ;

Grimberg, A. ;

Haymond, M. ;

Higham, C. ;

Ho, K. ;

Hoffman, A. R. ;

Hokken-Koelega, A. ;

Johannsson, G. ;

Juul, A. ;

Kopchick, J. ;

Lee, P. ;

Pollak, M. ;

Radovick, S. ;

Robison, L. ;

Rosenfeld, R. ;

Ross, R. J. ;

Savendahl, L. ;

Saenger, P. ;

Sorensen, H. Toft ;

Stochholm, K. ;

Strasburger, C. ;

Swerdlow, A. ;

Thorner, M. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2016, 174 (02) :P1-P9

[3]

Ayyagari R, 2017, AM HEALTH DRUG BENEF, V10, P408

[4] Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement [J].

Boguszewski, Margaret C. S. ;

Boguszewski, Cesar L. ;

Chemaitilly, Wassim ;

Cohen, Laurie E. ;

Gebauer, Judith ;

Higham, Claire ;

Hoffman, Andrew R. ;

Polak, Michel ;

Yuen, Kevin C. J. ;

Alos, Nathalie ;

Antal, Zoltan ;

Bidlingmaier, Martin ;

Biller, Beverley M. K. ;

Brabant, George ;

Choong, Catherine S. Y. ;

Cianfarani, Stefano ;

Clayton, Peter E. ;

Coutant, Regis ;

Cardoso-Demartini, Adriane A. ;

Fernandez, Alberto ;

Grimberg, Adda ;

Gudmundsson, Kolbeinn ;

Guevara-Aguirre, Jaime ;

Ho, Ken K. Y. ;

Horikawa, Reiko ;

Isidori, Andrea M. ;

Jorgensen, Jens Otto Lunde ;

Kamenicky, Peter ;

Karavitaki, Niki ;

Kopchick, John J. ;

Lodish, Maya ;

Luo, Xiaoping ;

McCormack, Ann, I ;

Meacham, Lillian ;

Melmed, Shlomo ;

Moab, Sogol Mostoufi ;

Muller, Hermann L. ;

Neggers, Sebastian J. C. M. M. ;

Aguiar Oliveira, Manoel H. ;

Ozono, Keiichi ;

Pennisi, Patricia A. ;

Popovic, Vera ;

Radovick, Sally ;

Savendahl, Lars ;

Touraine, Philippe ;

van Santen, Hanneke M. ;

Johannsson, Gudmundur .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2022, 186 (06) :P35-P52

[5] Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial [J].

Brauner, Raja ;

Serreau, Raphael ;

Souberbielle, Jean-Claude ;

Pouillot, Monique ;

Grouazel, Sophie ;

Recasens, Christophe ;

Zerah, Michel ;

Sainte-Rose, Christian ;

Treluyer, Jean-Marc .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (12) :4825-4833

[6] Anterior Hypopituitarism in Adult Survivors of Childhood Cancers Treated With Cranial Radiotherapy: A Report From the St Jude Lifetime Cohort Study [J].

Chemaitilly, Wassim ;

Li, Zhenghong ;

Huang, Sujuan ;

Ness, Kirsten K. ;

Clark, Karen L. ;

Green, Daniel M. ;

Barnes, Nicole ;

Armstrong, Gregory T. ;

Krasin, Matthew J. ;

Srivastava, Deo Kumar ;

Pui, Ching-Hon ;

Merchant, Thomas E. ;

Kun, Larry E. ;

Gajjar, Amar ;

Hudson, Melissa M. ;

Robison, Leslie L. ;

Sklar, Charles A. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (05) :492-U160

[7] Safety of Growth Hormone Treatment in Patients Previously Treated for Cancer [J].

Chemaitilly, Wassim ;

Robison, Leslie L. .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2012, 41 (04) :785-+

[8] Three-Year Outcomes of Bariatric Surgery vs Lifestyle Intervention for Type 2 Diabetes Mellitus Treatment A Randomized Clinical Trial [J].

Courcoulas, Anita P. ;

Belle, Steven H. ;

Neiberg, Rebecca H. ;

Pierson, Sheila K. ;

Eagleton, Jessie K. ;

Kalarchian, Melissa A. ;

DeLany, James P. ;

Lang, Wei ;

Jakicic, John M. .

JAMA SURGERY, 2015, 150 (10) :931-940

[9] Long-term outcomes in patients with adult-onset craniopharyngioma [J].

Dogra, Prerna ;

Bedatsova, Lucia ;

Van Gompel, Jamie J. ;

Giannini, Caterina ;

Donegan, Diane M. ;

Erickson, Dana .

ENDOCRINE, 2022, 78 (01) :123-134

[10] Assessment of hyperphagia in Prader-Willi syndrome [J].

Dykens, Elisabeth M. ;

Maxwell, Melissa A. ;

Pantino, Elizabeth ;

Kossler, Rebecca ;

Roof, Elizabeth .

OBESITY, 2007, 15 (07) :1816-1826

← 1 2 3 4 5 6 7 8 →