Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior

被引:6
|
作者
Zernov, Nikita [1 ]
Popugaeva, Elena [1 ]
机构
[1] Peter Great St Petersburg Polytech Univ, Lab Mol Neurodegenerat, St Petersburg 195251, Russia
关键词
TRPC6; neuroprotection; memory; behavior; OPERATED CALCIUM-ENTRY; TRANSIENT RECEPTOR; ALZHEIMERS-DISEASE; CATION CHANNEL; NMDA RECEPTORS; BRAIN-DAMAGE; RAT MODEL; HYPERFORIN; ACTIVATION; EXPRESSION;
D O I
10.3390/ijms242015415
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synaptoprotective signaling pathways, including antagonism of N-methyl-D-aspartate receptor (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic store-operated calcium entry. Positive regulation of TRPC6 channels has been repeatedly shown to be good for memory formation and storage. TRPC6 is mainly expressed in the hippocampus, particularly in the dentate granule cells, cornu Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic interneurons. It has been observed that TRPC6 agonists have a great influence on animal behavior including memory formation and storage The purpose of this review is to collect the available information on the role of TRPC6 in memory formation in various parts of the brain to understand how TRPC6-specific pharmaceutical agents will affect memory in distinct parts of the central nervous system (CNS).
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页数:16
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