Predictive Value of the C-Reactive Protein to Albumin Ratio in 30-Day Mortality after Hip Fracture in Elderly Population: A Retrospective Observational Cohort Study

被引:4
作者
Cacciola, Giorgio [1 ]
Mancino, Fabio [2 ]
Holzer, Lukas A. A. [2 ]
De Meo, Federico [1 ]
De Martino, Ivan [3 ,4 ]
Bruschetta, Antongiulio [1 ]
Risitano, Salvatore [5 ]
Sabatini, Luigi [5 ]
Cavaliere, Pietro [1 ]
机构
[1] Orthopaed Inst Southern Italy Franco Scalabrino, I-98165 Messina, Italy
[2] Fiona Stanley Fremantle Hosp Grp, Orthopaed Res Fdn Western Australia ORFWA, Dept Orthopaed, Perth, WA 6150, Australia
[3] Univ Cattolica Sacro Cuore, Largo Francesco Vito,1, I-00168 Rome, Italy
[4] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Ageing Orthopaed & Rheumatol Sci, Div Sports Traumatol & Joint Replacement, Adult Reconstruct & Joint Replacement Unit, I-00168 Rome, Italy
[5] Univ Torino, Ctr Traumatol Ortoped CTO, AOU Citta Salute & Sci, I-10024 Turin, Italy
关键词
femoral fractures; early mortality; C-reactive protein; albumin; arthroplasty; femoral nailing; intramedullary nail; total hip arthroplasty; elderly patients; ACETABULAR BONE LOSS; SURVIVAL; SURGERY; MARKER;
D O I
10.3390/jcm12134544
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: C-reactive protein (CRP) to Albumin ratio (CAR) has been used in multiple clinical settings to predict early mortality. However, there is a lack of evidence on the predictive role of CAR in 30-day mortality after a hip fracture. The purpose of this study was to establish a potential association between CAR and 30-day mortality and to assess if the CAR Receiving Operating Characteristics curve (ROC) can be a reliable predictor of early mortality. Methods: We retrospectively reviewed the charts of 676 patients (>65 years) treated for hip fracture between 2006 and 2018. All hip fractures were included. Treatment strategies included closed reduction and internal fixation, open reduction and internal fixation, hemiarthroplasty, or total joint arthroplasty. Statistical analysis included T-test, Pearson correlation for CAR and other markers, ROC curves and area under the curve, Youden Model, and Odds Ratio. Results: The 30-day mortality rate analysis showed that higher preoperative levels of CAR were associated with higher early mortality. When analyzing the area under the ROC curve (AUROC) for 30-day mortality, the reported value was 0.816. The point of the ROC curve corresponding to 14.72 was considered a cut-off with a specificity of 87% and a sensibility of 40.8%. When analyzing values higher than 14.72, the 30-day mortality rate was 17.9%, whilst, for values lower than 14.72, the 30-day mortality rate was 1.8%. Conclusions: Patients older than 65 years affected by a hip fracture with increased preoperative levels of CAR are associated with higher 30-day mortality. Despite a moderate sensibility, considering the low cost and the predictivity of CAR, it should be considered a standard predictive marker.
引用
收藏
页数:12
相关论文
共 50 条
  • [41] Predictive Value of the New Inflammatory Score Based on C-reactive Protein to Albumin Ratio on Serious Postoperative Complications after Curative Pancreaticoduodenectomy for Pancreatic Adenocarcinoma
    Mercan, Umit
    Ersen, Ogun
    Yuksel, Cemil
    Unal, Ali Ekrem
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020, 14 (09)
  • [42] Preoperative C-reactive protein/albumin ratio to predict mortality and recurrence of patients with hepatocellular carcinoma after curative resection
    Ren, Yiyue
    Fan, Xiaoxiao
    Chen, Guoqiao
    Zhou, Daizhan
    Lin, Hui
    Cai, Xiujun
    MEDICINA CLINICA, 2019, 153 (05): : 183 - 190
  • [43] Role of serum C-reactive protein (CRP)/Albumin ratio in predicting the severity of acute pancreatitis: A retrospective cohort
    Kazmi, Syed Jawad Haider
    Zafar, Muhammad Talha
    Zia, Beenish Fatima
    Khalid, Saleha Rashid
    Kumar, Vikesh
    Tabassum, Shaesta
    Ali, Ahmed
    Aziz, Nouman
    Khan, Noman Ahmed
    Kumari, Kanchan
    Saleem, Kanza
    Asghar, Muhammad Sohaib
    ANNALS OF MEDICINE AND SURGERY, 2022, 82
  • [44] A retrospective study on the prognostic value of preoperative C-reactive protein to albumin ratio in patients with oral cavity squamous cell carcinoma
    Fang, Ku-Hao
    Lai, Chia-Hsuan
    Hsu, Cheng-Ming
    Huang, Ethan
    Tsai, Ming-Shao
    Chang, Geng He
    Lee, Yi-Chan
    Tsai, Yao-Te
    PEERJ, 2020, 8
  • [45] Assessment of the relationship between C-Reactive Protein/Albumin ratio and 28-day mortality in critically very elderly patients (? 85 years) with acute ischemic stroke
    Soylu, Veysel G.
    Karahan, Esma
    Yilmaz, Ayse
    Taskin, Ozturk
    Demir, Ufuk
    NEUROLOGY ASIA, 2022, 27 (03) : 575 - 581
  • [46] The prognostic value of C-reactive protein and albumin in patients undergoing resection of colorectal liver metastases. A retrospective cohort study
    Fruhling, Petter
    Hellberg, Katarina
    Ejder, Patric
    Stromberg, Cecilia
    Urdzik, Jozef
    Isaksson, Bengt
    HPB, 2021, 23 (06) : 970 - 978
  • [47] Length of Hospital Stay for Hip Fracture and 30-Day Mortality in People With Alzheimer's Disease: A Cohort Study in Finland
    Lavikainen, Piia
    Koponen, Marjaana
    Taipale, Heidi
    Tanskanen, Antti
    Tiihonen, Jari
    Hartikainen, Sirpa
    Tolppanen, Anna-Maija
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2020, 75 (11): : 2184 - 2192
  • [48] C-reactive protein level predicts 30-day mortality and bleeding in patients with venous thromboembolism: A prospective single-center study
    Demelo-Rodriguez, Pablo
    Galeano-Valle, Francisco
    Marcelo-Ayala, Almudena
    Fernandez-Carracedo, Eduardo
    Cuenca-Zarzuela, Alicia
    Gomez-Morales, Marina
    Antonio Alvarez-Sala-Walther, Luis
    Maria Bellon-Cano, Jose
    del-Toro-Cervera, Jorge
    MEDICINA CLINICA, 2020, 155 (02): : 51 - 56
  • [49] The FRAIL-FIT 30 Study - Factors influencing 30-day mortality in frail patients admitted to ICU: A retrospective observational cohort study
    Hewitt, David
    Ratcliffe, Michael
    Booth, Malcolm G.
    JOURNAL OF THE INTENSIVE CARE SOCIETY, 2022, 23 (02) : 150 - 161
  • [50] Performance of the Nottingham hip fracture score (NHFS) as a predictor of 30-day mortality after proximal femur fracture in an older people Brazilian cohort
    Ferro, Flavio Cruz
    Campos, Marcos Adriano Garcia
    Picolli, Thais Caroline Silva
    Mayoral, Vania de Sa
    Soares, Victoria Moralez
    Ferreira, Jessica Caroline
    Peres, Lucas Dias Borges
    Tibeau, Theodor Terra Mayer
    Bernardi, Victor El Chihimi
    Pereira, David Nascimento
    Gumieiro, David Nicoletti
    Curcelli, Emilio Carlos
    Navarro e Lima, Lais Helena
    do Nascimento Junior, Paulo
    Lazzarin, Taline
    Ballarin, Raquel Simoes
    Okoshi, Marina Politi
    Minicucci, Marcos Ferreira
    de Paiva, Sergio Alberto Rupp
    Gordon, Adam Lee
    Sahota, Opinder
    Pereira, Filipe Welson Leal
    Azevedo, Paula Schmidt
    SCIENTIFIC REPORTS, 2025, 15 (01):