New Insights and Potential Therapeutic Interventions in Metabolic Diseases

被引：57

作者：

Clemente-Suarez, Vicente Javier ^{[1
,2
]}

Martin-Rodriguez, Alexandra ^{[1
]}

Redondo-Florez, Laura ^{[3
]}

Lopez-Mora, Clara ^{[4
]}

Yanez-Sepulveda, Rodrigo ^{[5
]}

Tornero-Aguilera, Jose Francisco ^{[1
]}

机构：

[1] Univ Europea Madrid, Fac Sports Sci, Tajo St,S N, Madrid 28670, Spain

[2] Univ Costa, Grp Invest Cultura Educ & Soc, Barranquilla 080002, Colombia

[3] Univ Europea Madrid, Fac Biomed & Hlth Sci, Dept Hlth Sci, Tajo St S N, Villaviciosa de Odon 28670, Spain

[4] Univ Europea Valencia, Fac Ciencias Biomed & Salud, Pg Albereda 7, Valencia 46010, Spain

[5] Univ Andres Bello, Fac Educ & Social Sci, Vina del Mar 2520000, Chile

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期

关键词：

genetic; psychology; single-cell transcriptomics; gut; epigenetics; advanced imaging techniques; cell-based therapies; microbiota; nutrition; physical activity; BROWN ADIPOSE-TISSUE; MESENCHYMAL STEM-CELLS; FECAL MICROBIOTA TRANSPLANTATION; INSULIN-PRODUCING CELLS; CARDIOMETABOLIC RISK-FACTORS; TYPE-2; DIABETES-MELLITUS; EARLY-LIFE NUTRITION; FATTY LIVER-DISEASE; HUMAN BONE-MARROW; GUT MICROBIOTA;

D O I：

10.3390/ijms241310672

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.

引用

页数：45

共 352 条

[1] Epigenetic modifications of gene expression by lifestyle and environment [J].

Abdul, Qudeer Ahmed ;

Yu, Byung Pal ;

Chung, Hae Young ;

Jung, Hyun Ah ;

Choi, Jae Sue .

ARCHIVES OF PHARMACAL RESEARCH, 2017, 40 (11) :1219-1237

[2] Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights [J].

Adcock, Ian M. ;

Caramori, Gaetano ;

Barnes, Peter J. .

RESPIRATION, 2011, 81 (04) :265-284

[3] Prevalence of the Metabolic Syndrome in the United States, 2003-2012 [J].

Aguilar, Maria ;

Bhuket, Taft ;

Torres, Sharon ;

Liu, Benny ;

Wong, Robert J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (19) :1973-1974

[4]

Aguirre P., 2004, Ricos flacos y gordos pobres

[5]

Al Aboud N.M., 2023, Genetics, epigenetic mechanism. StatPearls

[6] Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression [J].

Alagpulinsa, David A. ;

Cao, Jenny J. L. ;

Driscol, Riley K. ;

Sirbulescu, Ruxandra F. ;

Penson, Madeline F. E. ;

Sremac, Marinko ;

Engquist, Elise N. ;

Brauns, Timothy A. ;

Markmann, James F. ;

Melton, Douglas A. ;

Poznansky, Mark C. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 (07) :1930-1940

[7] Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies [J].

Aleksandrova, Krasimira ;

Koelman, Liselot ;

Rodrigues, Caue Egea .

REDOX BIOLOGY, 2021, 42

[8] New Advances in Metabolic Syndrome, from Prevention to Treatment: The Role of Diet and Food [J].

Ambroselli, Donatella ;

Masciulli, Fabrizio ;

Romano, Enrico ;

Catanzaro, Giuseppina ;

Besharat, Zein Mersini ;

Massari, Maria Chiara ;

Ferretti, Elisabetta ;

Migliaccio, Silvia ;

Izzo, Luana ;

Ritieni, Alberto ;

Grosso, Michela ;

Formichi, Caterina ;

Dotta, Francesco ;

Frigerio, Francesco ;

Barbiera, Eleonora ;

Giusti, Anna Maria ;

Ingallina, Cinzia ;

Mannina, Luisa .

NUTRIENTS, 2023, 15 (03)

[9] The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease [J].

Anders, Hans-Joachim ;

Andersen, Kirstin ;

Stecher, Baerbel .

KIDNEY INTERNATIONAL, 2013, 83 (06) :1010-1016

[10] Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis [J].

Andralojc, K. ;

Srinivas, M. ;

Brom, M. ;

Joosten, L. ;

de Vries, I. J. M. ;

Eizirik, D. L. ;

Boerman, O. C. ;

Meda, P. ;

Gotthardt, M. .

DIABETOLOGIA, 2012, 55 (05) :1247-1257

← 1 2 3 4 5 6 7 8 9 10 →