Synthesis and characterization of a new gold-coated magnetic nanoparticle decorated with a thiol-containing dendrimer for targeted drug delivery, hyperthermia treatment and enhancement of MRI contrast agent

被引：17

作者：

Nori, Zahra Zamani ^{[1
]}

Bahadori, Mehrnaz ^{[1
]}

Moghadam, Majid ^{[1
]}

Tangestaninejad, Shahram ^{[1
]}

Mirkhani, Valiollah ^{[1
]}

Mohammadpoor-Baltork, Iraj ^{[1
]}

Jafari, S. Shahrbanoo ^{[2
]}

Emamzadeh, Rahman ^{[2
]}

Alem, Halima ^{[3
]}

机构：

[1] Univ Isfahan, Dept Chem, Catalysis Div, Esfahan 8174673441, Iran

[2] Univ Isfahan, Fac Biol Sci & Technol, Dept Cell & Mol Biol & Microbiol, Esfahan, Iran

[3] Univ Lorraine, CNRS, IJL, F-54000 Nancy, France

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 81卷

基金：

美国国家科学基金会;

关键词：

Drug delivery; Dendrimer; Magnetic nanoparticle; MRI contrast Agent; Hyperthermia; 6-mercaptopurine;

D O I：

10.1016/j.jddst.2023.104216

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A unique multi-functional magnetic nanocarrier containing thiol groups was designed and applied in drug de-livery, hyperthermia and as a contrast agent in MRI. The polymeric nanoparticles were prepared by modification of Fe3-delta O4@Au magnetic nanoparticles with a thiol-ended dendrimer. This platform introduces suitable carriers through the grafting of thiol-ended dendrimer for the further binding of an anticancer drug as 6-mercaptopurine (6-MP). The drug is released when exposed to the reductive environmental conditions of cancer cells. Cyto-toxicity of the MNP-CC2-6-MP with human breast cancer cell line MCF-7 was examined. Also, the MNP, MNP@Au, and MNP-CC2 nanomaterials were used as magnetic hyperthermia tools and as a contrast agent in MRI and the results were compared with each other. The effect of RF hyperthermia and the released drug in cancer cells were simultaneously investigated as well and confirmed the therapeutic efficiency of those new composite nanomaterials. This magneto dendrimer with multimodal cancer therapy can be selected as an ideal source for biomedicine study.

引用

页数：11