Risk factors for perinatal stroke in term infants: A case-control study in Australia

被引：6
作者：
Roy, Bithi [1 ,2 ,3 ,7 ]
Webb, Annabel [4 ]
Walker, Karen [2 ,5 ]
Morgan, Catherine [1 ,4 ]
Badawi, Nadia [1 ,4 ,6 ]
Novak, Iona [2 ,4 ]
机构：
[1] Univ Sydney, Childrens Hosp, Westmead Clin Sch, Sydney, NSW, Australia
[2] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia
[3] Univ Notre Dame Australia, Sydney, NSW, Australia
[4] Univ Sydney, Cerebral Palsy Alliance Res Inst, Discipline Child & Adolescent Hlth, Sydney, NSW, Australia
[5] Sydney Local Hlth, RPA Newborn Care, Sydney, NSW, Australia
[6] Childrens Hosp Westmead, Grace Ctr Newborn Intens Care, Sydney, NSW, Australia
[7] North ShoreHealth Hub, Suite A3 09,Level 3 Tower,7 Westbourne St, Sydney, NSW 2065, Australia
来源：
JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2023年 / 59卷 / 04期
关键词：
aetiology; neonatology; neurology; perinatal stroke; risk factors; ARTERIAL ISCHEMIC-STROKE; EPIDEMIOLOGY; MECHANISMS; OUTCOMES;
D O I：
10.1111/jpc.16372
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
AimThe aetiology of perinatal stroke is poorly understood. This study aimed to prospectively confirm the risk factors and identify any previously unknown variables. MethodsA prospective case-control study was conducted in Australia. Univariate odds ratios (ORs), associated 95% confidence intervals (CIs) and multivariable logistic regression models fitted with backwards stepwise variable selection were used. ResultsSixty perinatal stroke cases reported between 2017 and 2019 included 95% (57/60) with multiple risk factors. Univariate analysis identified emergency caesarean section rather than NVD (P < 0.01), low Apgar score (<7) at 1, 5 and 10 min of age (P < 0.01), resuscitation at birth (P < 0.01), abnormal cord blood gas (P < 0.01), neonatal infection/sepsis (P < 0.01), congenital heart disease (P < 0.01) and hypoglycaemia (P < 0.01) as significant risk factors. Multivariate analysis found smoking during pregnancy (OR: 1.48; 95% CI: 1.09-1.99), 1-min Apgar score < 7 (OR: 1.54; 95% CI: 1.15-2.08), 10-min Apgar score < 7 (OR: 1.26; 95% CI: 1.02-1.54) and hypoglycaemia (OR: 1.49; 95% CI: 1.07-2.06). ConclusionsPerinatal stroke is associated with multiple risk factors. Exposure to smoking, 10-min Apgar score < 7, neonatal infection and hypoglycaemia were independent risk factors. Emergency caesarean section, resuscitation at birth and abnormal cord blood gas were additional risk factors.
引用
收藏
页码：673 / 679
页数：7
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