The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells

被引：25
作者：
Giannotta, Claudia [1 ]
Autino, Federica [1 ]
Massaia, Massimo [1 ,2 ]
机构：
[1] Univ Torino, Ctr Interdipartimentale Biotecnol Mol Guido Tarone, Dipartimento Biotecnol Mol & Sci Salute, Lab Immunol Tumori Sangue LITS, Turin, Italy
[2] AO S Croce & Carle, SC Ematol, Cuneo, Italy
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 13卷
关键词：
MDSC (myeloid-derived suppressor cell); TME (tumor microenvironment); multiple myeloma; Immunothearpies; immune suppression; BONE-MARROW MICROENVIRONMENT; REGULATORY CELLS; DENDRITIC CELLS; T-CELLS; INHIBITION; ANGIOGENESIS; ACTIVATION; SUBPOPULATIONS; DARATUMUMAB; PROGRESSION;
D O I：
10.3389/fimmu.2022.1102471
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the tumor microenvironment (TME) with direct and indirect mechanisms: production of soluble factors and cytokines, expression of surface inhibitory molecules, metabolic rewiring and exosome release. The two-way relationship between MDSC and tumor cells results in immune evasion and cancer outgrowth. In multiple myeloma (MM), MDSC play a major role in creating protumoral TME conditions. In this minireview, we will discuss the interplay between MDSC and MM TME and the possible strategies to target MDSC.
引用
收藏
页数：8
相关论文
共 85 条
[1]   Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation [J].
Ai, Lisha ;
Mu, Shidai ;
Sun, Chunyan ;
Fan, Fengjuan ;
Yan, Han ;
Qin, You ;
Cui, Guohui ;
Wang, Yadan ;
Guo, Tao ;
Mei, Heng ;
Wang, Huafang ;
Hu, Yu .
MOLECULAR CANCER, 2019, 18 (1)
[2]   Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication [J].
An, Gang ;
Acharya, Chirag ;
Feng, Xiaoyan ;
Wen, Kenneth ;
Zhong, Mike ;
Zhang, Li ;
Munshi, Nikhil C. ;
Qiu, Lugui ;
Tai, Yu-Tzu ;
Anderson, Kenneth C. .
BLOOD, 2016, 128 (12) :1590-1603
[3]   Interleukin-6 in bone metastasis and cancer progression [J].
Ara, Tasnim ;
DeClerck, Yves A. .
EUROPEAN JOURNAL OF CANCER, 2010, 46 (07) :1223-1231
[4]   Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance [J].
Belisario, Dimas Carolina ;
Kopecka, Joanna ;
Pasino, Martina ;
Akman, Muhlis ;
De Smaele, Enrico ;
Donadelli, Massimo ;
Riganti, Chiara .
CELLS, 2020, 9 (12)
[5]   Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma [J].
Binsfeld, Marilene ;
Muller, Josephine ;
Lamour, Virginie ;
De Veirman, Kim ;
De Raeve, Hendrik ;
Bellahcene, Akeila ;
Van Valckenborgh, Els ;
Baron, Frederic ;
Beguin, Yves ;
Caers, Jo ;
Heusschen, Roy .
ONCOTARGET, 2016, 7 (25) :37931-37943
[6]   Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma [J].
Brimnes, M. K. ;
Vangsted, A. J. ;
Knudsen, L. M. ;
Gimsing, P. ;
Gang, A. O. ;
Johnsen, H. E. ;
Svane, I. M. .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 72 (06) :540-547
[7]   Metabolic approaches to rescue antitumor Vγ9Vδ2 T-cell functions in myeloma [J].
Castella, Barbara ;
Riganti, Chiara ;
Massaia, Massimo .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2020, 25 :69-105
[8]   Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma [J].
Castella, Barbara ;
Foglietta, Myriam ;
Sciancalepore, Patrizia ;
Rigoni, Micol ;
Coscia, Marta ;
Griggio, Valentina ;
Vitale, Candida ;
Ferracini, Riccardo ;
Saraci, Elona ;
Omede, Paola ;
Riganti, Chiara ;
Palumbo, Antonio ;
Boccadoro, Mario ;
Massaia, Massimo .
ONCOIMMUNOLOGY, 2015, 4 (11)
[9]   Vγ9Vδ2 T cell-based immunotherapy in hematological malignancies: from bench to bedside [J].
Castella, Barbara ;
Vitale, Candida ;
Coscia, Marta ;
Massaia, Massimo .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (14) :2419-2432
[10]   Daratumumab With Cetrelimab, an Anti-PD-1 Monoclonal Antibody, in Relapsed/Refractory Multiple Myeloma [J].
Cohen, Yael C. ;
Oriol, Albert ;
Wu, Ka Lung ;
Lavi, Noa ;
Vlummens, Philip ;
Jackson, Carolyn ;
Garvin, Wendy ;
Carson, Robin ;
Crist, Wendy ;
Fu, Jiayu ;
Feng, Huaibao ;
Xie, Hong ;
Schecter, Jordan ;
San-Miguel, Jesus ;
Lonial, Sagar .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 (01) :46-+
123456789