Lignans and a neolignan from an aqueous extract of Isatis indigotica roots

被引：1
作者：
Wang, Lei [1 ]
Chen, Ming-Hua [1 ]
Liu, Yu-Feng [1 ]
Meng, Ling-Jie [1 ]
Guo, Qing-Lan [1 ]
Shi, Jian-Gong [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 03期
关键词：
Cruciferae; Isatis indigotica; sulfonated lignan and neolignan; cyclolignan glucoside; antiviral activity; BAN LAN GEN; ENANTIOMERS; ALKALOIDS; DERIVATIVES; GLUCOSIDES; SKELETON;
D O I：
10.1080/10286020.2022.2089979
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new lignans (1-4) and one new neolignan (5), along with two known lignan derivatives (6 and 7), were isolated from an aqueous extract of the Isatis indigotica root (ban lan gen). Their structures were determined by spectroscopic data analysis, chemical method, and theoretical calculation, for which 1 was proved by single-crystal X-ray diffraction. Compound 2 exhibited antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with an IC50 value of 11.1 mu M and a selective index (SI) > 9, while 1 and 5 are the first examples of sulfonated lignan and neolignan from nature.
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页码：205 / 217
页数：13
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