Inflammatory Cells and Lipid Deposits Detected by in Vivo Confocal Microscopy in Brimonidine Tartrate Ophthalmic Solution-Related Corneal Disorders: A Case Series

被引：0
作者：
Chikama, Taiichiro [1 ]
Shinji, Koichiro [1 ]
Yokota, Chika [1 ]
Hayashi, Ken [2 ]
Kiuchi, Yoshiaki [1 ]
机构：
[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Ophthalmol & Visual Sci, Hiroshima, Japan
[2] Hayashi Eye Hosp, Fukuoka, Japan
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2023年 / 31卷 / 09期
关键词：
Brimonidine tartrate; confocal microscopy; corneal opacity; dendritic cells; drug-related side effects and adverse reactions; glaucoma; lipids; neutrophils;
D O I：
10.1080/09273948.2022.2137045
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
We reviewed the medical charts of five patients diagnosed with brimonidine tartrate (BT)-related corneal disorders. A fan-shaped corneal opacity was present in four patients and limbal corneal infiltrations were present in one patient. In vivo confocal microscopy revealed dendritic cells and lipid deposits in the fan-shaped opacity as well as neutrophils in limbal infiltrations. BT instillation was discontinued and topical administration of a corticosteroid was initiated for all patients. The limbal infiltrations improved after BT discontinuation. Conversely, the fan-shaped opacity remained in all affected patients. After a fan-shaped opacity has developed in a patient with a BT-related corneal disorder, the lesion is difficult to resolve. However, limbal infiltrations respond well to treatment. Therefore, BT should be discontinued and anti-inflammatory treatment initiated before a fan-shaped opacity forms.
引用
收藏
页码：1842 / 1847
页数：6
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