The Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in Rheumatoid Arthritis

被引：0
作者：
Abaszadeh, Amir [1 ]
Salehi, Oveis [2 ]
Badali, Ahmadreza [3 ]
Lavanmardi, Dorsa [4 ]
Sarlak, Alireza [5 ]
Lotfalian, Azam [6 ]
Poudineh, Maryam [1 ,7 ,8 ]
机构：
[1] Ilam Univ, Sch Med, Ilam, Iran
[2] Univ Tehran Med Sci, Tehran, Iran
[3] Tabriz Univ Med Sci, Res Ctr Connect Tissue Dis, Tabriz, Iran
[4] Fars Stem Cell Res Inst, Shiraz, Fars, Iran
[5] Hamadan Univ Med Sci, Student Res Comm, Sch Med, Hamadan, Iran
[6] Shahid Sadoughi Univ Med Sci, Dept Biol & Anat Sci, Yazd, Iran
[7] Mashhad Azad Univ, Sch Med, Mashhad, Iran
[8] Islamic Azad Univ, Sch Med, Mashhad Branch, Mashhad, Iran
来源：
GALEN MEDICAL JOURNAL | 2023年 / 12卷
关键词：
Rheumatoid Arthritis; Mesenchymal Stem Cell; Extracellular Vesicle; Exosome; STEM-CELLS; THERAPY; AMELIORATION; EXOSOMES; SAFETY;
D O I：
10.31661/gmj.v12i.3075
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There is presently no cure for the chronic inflammatory disease rheumatoid arthritis (RA), which affects the joints and other organs. Mesenchymal stem/stromal cells (MSCs) are adult stem cells that are widely studied in inflammatory diseases. Several studies have shown the therapeutic effects of MSCs in preclinical and clinical RA. However, there are a few concerns regarding the use of MSCs, such as immune rejection and malignancy. Since MSCs exert their potential effects in a paracrine manner, more attention has been paid to their extracellular vesicles (MSC-EVs). In the current study, we reviewed the application of MSCs and their EVs in RA. A better understanding of the mechanisms driving MSC and MSC-EVs in RA offers insight into possible treatment options for RA. [GMJ.2023
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页数：7
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