Three-component one-pot metal-free synthesis of 2,3-dihydroquinazolin-4(1H)-ones using Mukaiyama's reagent

被引：0
作者：
Kumar, Ashish [1 ,2 ]
Gupta, Monika [2 ]
Rajput, Chatrasal S. [1 ]
机构：
[1] Jubilant Biosys Ltd, Chem Innovat Res Ctr, Knowledge Pk 2, Greater Noida 201310, Uttar Pradesh, India
[2] Babu Banarasi Das Univ, Sch Basic Sci, Dept Chem, Lucknow 227015, Uttar Pradesh, India
来源：
ARKIVOC | 2023年
关键词：
Mukaiyama's Reagent; dihydroquinazolin-4(1H)-ones; isatoic anhydride; aromatic aldehydes; coupling reaction; EFFICIENT SYNTHESIS; HETEROGENEOUS CATALYST; AQUEOUS-MEDIA; NANOPARTICLES; DERIVATIVES; WATER; ACID; QUINAZOLIN-4(3H)-ONES; INHIBITORS; AMINES;
D O I：
10.24820/ark.5550190.p012.066
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid, effective, without transition metal and column chromatography-free protocol for the synthesis of 2,3dihydroquinazolinones (DHQ) derivatives via one-pot tri-component reaction using amine, aldehyde (aromatic or aliphatic) and isatoic anhydride in the existence of Mukaiyama's reagent (CMPI: 2-chloro-1-methylpyridinium iodide) has been developed with commendable isolated yields. The operation is a high atom economy experimental procedure, with good functional group tolerance, broad substrate scope, and gives high yields in a short period. The trace metal contamination in synthesized pharmaceuticals is a big issue, the metal-free conditions is the highlighted advantage in solving this issue. [GRAPHICS] .
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页数：14
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