Bleeding Diathesis as the Initial Presentation of Chronic Myeloid Leukemia: A Case Series

被引：0

作者：

AlGahtani, Farjah H. ^{[1
]}

Alshaman, Leena ^{[1
]}

ElGohary, Ghada ^{[2
,3
]}

Aleem, Aamer ^{[1
]}

AlQahtany, Fatmah S. ^{[4
]}

机构：

[1] King Saud Univ, King Saud Univ Med City, Coll Med, Div Hematol Oncol,Dept Med, Riyadh, Saudi Arabia

[2] King Saud Univ, King Saud Univ Med City, Coll Med, Hematol Oncol,Div Hematol Oncol, Riyadh, Saudi Arabia

[3] Ain Shams Univ, Fac Med, Dept Adult Hematol Internal Med, Cairo, Egypt

[4] King Saud Univ, King Saud Univ Med City, Coll Med, Hematopathol Unit,Dept Pathol, Riyadh, Saudi Arabia

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 04期

关键词：

bcr-abl; tyrosine kinase inhibitor (tki); chronic phase; philadelphia chromosome; chronic myeloid leukemia;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia chromosome. CML is classified into three stages: chronic, accelerated, and blast. It has been widely recognized that the likelihood of developing CML varies by gender, geography, and age. In the chronic phase of CML (CML-CP), bleeding is a rare sign since the thrombocyte and coagulation functions are still adequate. Uncertainties exist regarding the CML bleeding mechanism. We report four cases of CML-CP in adult patients. The majority of these patients had CML and had idiopathic spontaneous bleeding in multiple locations.

引用

页数：6