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miR-383-5p serves as a tumor suppressor in bladder cancer by suppressing PI3K/AKT signaling pathway
被引:6
作者:

Liu, Yu
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机构:
Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China
Chongqing Tradit Chinese Med Hosp, Dept Urol, Chongqing, Peoples R China Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China

Yu, Haitao
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Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China

Zeng, Bin
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机构:
Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, Chongqing, Peoples R China Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China

Gou, Xin
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Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China

Ren, Ke
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Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China

Yuan, Fangchao
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h-index: 0
机构:
Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China
机构:
[1] Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China
[2] Chongqing Tradit Chinese Med Hosp, Dept Urol, Chongqing, Peoples R China
[3] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, Chongqing, Peoples R China
关键词:
miR-383-5p;
PI3KR1;
AKT;
bladder cancer;
PROLIFERATION;
MICRORNAS;
MIGRATION;
CELLS;
D O I:
10.3233/CBM-220379
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
BACKGROUND: MicroRNAs have been proven to be key molecules in human malignancy. However, to our knowledge, there is no study reporting miR-383-5p expression level and the role it plays in bladder cancer (BC). METHODS: We identified miR-383-5p to be one of the tumor-suppressing genes through using data from The Cancer Genome Atlas (TCGA) and GEO database. We evaluate the expression and activity of miR-383-5p in both BC tissue and cell lines. The impacts of miR-383-5p on proliferative, migratory ability and apoptotic rate in BC cell were evaluated by utilizing CCK-8 kits, flow cytometry, and Transwell assays. qRT-PCR, western blot, and luciferase reporter assays have been adopted to investigate the underlying mechanisms. In vivo tumorigenicity testing was conducted to determine the impact of miR-383-5p on BC cellular proliferative capacity. RESULTS: Reduced miR-383-5p expression has been determined in BC tissue than in normal bladder tissue. Furthermore, BC cell proliferative, migratory ability was inhibited while apoptosis enhanced in vitro and in vivo by miR-383-5p up-regulation. In vitro and in vivo, silencing miR-383-5p considerably improved the growth and invasive capacity of cell, while decreased the apoptotic rates of BC cells. CONCLUSION: miR-383-5p plays its role as a tumor-suppressing gene by suppressing the PI3K/AKT signaling, hence preventing the development of BC.
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页码:121 / 131
页数:11
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共 28 条
[21]
Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway
[J].
Sun, Ye
;
Liu, Wenjun
;
Zhao, Qiuyu
;
Zhang, Ruiqi
;
Wang, Jianbo
;
Pan, Pengyu
;
Shang, Hai
;
Liu, Chunying
;
Wang, Chun
.
FRONTIERS IN ONCOLOGY,
2021, 11

Sun, Ye
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China
Shenyang Med Coll, Key Lab Environm Pollut & Microecol Liaoning Prov, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Liu, Wenjun
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Teaching & Expt Ctr, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Zhao, Qiuyu
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ Tradit Chinese Med TCM Viscera State, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Zhang, Ruiqi
论文数: 0 引用数: 0
h-index: 0
机构:
Northeast Yucai Sch, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Wang, Jianbo
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ Tradit Chinese Med TCM Viscera State, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Pan, Pengyu
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Shang, Hai
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Liu, Chunying
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China

Wang, Chun
论文数: 0 引用数: 0
h-index: 0
机构:
Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China Liaoning Univ Tradit Chinese Med, Dept Cell Biol, Coll Integrated Chinese & Western Med, Shenyang, Peoples R China
[22]
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway
[J].
Tan, Lei
;
Tang, Yiming
;
Li, Hongbo
;
Li, Pengju
;
Ye, Yunlin
;
Cen, Junjie
;
Gui, Chengpeng
;
Luo, Junhang
;
Cao, Jiazheng
;
Wei, Jinhuan
.
FRONTIERS IN ONCOLOGY,
2021, 11

Tan, Lei
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Tang, Yiming
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Li, Hongbo
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Musculoskeletal Oncol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Li, Pengju
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Ye, Yunlin
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Canc Ctr, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Cen, Junjie
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Gui, Chengpeng
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Luo, Junhang
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Cao, Jiazheng
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Jiangmen Cent Hosp, Dept Urol, Affiliated Jiangmen Hosp, Jiangmen, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China

Wei, Jinhuan
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China Sun Yat Sen Univ, Dept Urol, Affiliated Hosp 1, Guangzhou, Peoples R China
[23]
Update on the guideline of guidelines: non-muscle-invasive bladder cancer
[J].
Taylor, Jacob
;
Becher, Ezequiel
;
Steinberg, Gary D.
.
BJU INTERNATIONAL,
2020, 125 (02)
:197-205

Taylor, Jacob
论文数: 0 引用数: 0
h-index: 0
机构:
NYU Langone Hlth, Dept Urol, New York, NY USA NYU Langone Hlth, Dept Urol, New York, NY USA

Becher, Ezequiel
论文数: 0 引用数: 0
h-index: 0
机构:
NYU Langone Hlth, Dept Urol, New York, NY USA NYU Langone Hlth, Dept Urol, New York, NY USA

Steinberg, Gary D.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU Langone Hlth, Dept Urol, New York, NY USA NYU Langone Hlth, Dept Urol, New York, NY USA
[24]
Downregulated miR-383-5p contributes to the proliferation and migration of gastric cancer cells and is associated with poor prognosis
[J].
Wei, Chao
;
Gao, Jian-Jun
.
PEERJ,
2019, 7

Wei, Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Jinzhou Med Univ, Dept Gen Surg, Hosp PLA Joint Logist Support Force 967, Postgrad Culture Base, Dalian, Peoples R China Jinzhou Med Univ, Dept Gen Surg, Hosp PLA Joint Logist Support Force 967, Postgrad Culture Base, Dalian, Peoples R China

Gao, Jian-Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Jinzhou Med Univ, Hosp PLA Joint Logist Support Force 967, Dept Gen Surg, Dalian, Peoples R China Jinzhou Med Univ, Dept Gen Surg, Hosp PLA Joint Logist Support Force 967, Postgrad Culture Base, Dalian, Peoples R China
[25]
Deoxyshikonin Inhibits Viability and Glycolysis by Suppressing the Akt/mTOR Pathway in Acute Myeloid Leukemia Cells
[J].
Wu, Huijuan
;
Zhao, Hongmian
;
Chen, Li
.
FRONTIERS IN ONCOLOGY,
2020, 10

Wu, Huijuan
论文数: 0 引用数: 0
h-index: 0
机构:
Henan Univ, Telemed & Connected Hlth Ctr, Huaihe Hosp, Kaifeng, Peoples R China Henan Univ, Telemed & Connected Hlth Ctr, Huaihe Hosp, Kaifeng, Peoples R China

Zhao, Hongmian
论文数: 0 引用数: 0
h-index: 0
机构:
Henan Univ, Dept Hematol, Huaihe Hosp, Kaifeng, Peoples R China Henan Univ, Telemed & Connected Hlth Ctr, Huaihe Hosp, Kaifeng, Peoples R China

Chen, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Henan Univ, Dept Hematol, Huaihe Hosp, Kaifeng, Peoples R China Henan Univ, Telemed & Connected Hlth Ctr, Huaihe Hosp, Kaifeng, Peoples R China
[26]
MicroRNA-383-5p acts as a potential prognostic biomarker and an inhibitor of tumor cell proliferation, migration, and invasion in breast cancer
[J].
Zhang, Jingwei
;
Kong, Xia
;
Shi, Qizhu
;
Zhao, Bin
.
CANCER BIOMARKERS,
2020, 27 (04)
:423-432

Zhang, Jingwei
论文数: 0 引用数: 0
h-index: 0
机构:
Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China

Kong, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Shanxian Cent Hosp, Dept Oncol, Heze, Shandong, Peoples R China Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China

Shi, Qizhu
论文数: 0 引用数: 0
h-index: 0
机构:
Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China

Zhao, Bin
论文数: 0 引用数: 0
h-index: 0
机构:
Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China Shanxian Cent Hosp, Dept Vasc & Thyroid & Breast Surg, 1 Wenhua Rd, Heze 274300, Shandong, Peoples R China
[27]
MiR-383 inhibits proliferation, migration and angiogenesis of glioma-exposed endothelial cells in vitro via VEGF-mediated FAK and Src signaling pathways
[J].
Zhao, Li-Ni
;
Wang, Ping
;
Liu, Yun-Hui
;
Cai, Heng
;
Ma, Jun
;
Liu, Li-Bo
;
Xi, Zhuo
;
Li, Zhi-Qing
;
Liu, Xiao-Bai
;
Xue, Yi-Xue
.
CELLULAR SIGNALLING,
2017, 30
:142-153

Zhao, Li-Ni
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
China Med Univ, Inst Pathol & Pathophysiol, Shenyang 110122, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Wang, Ping
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
China Med Univ, Inst Pathol & Pathophysiol, Shenyang 110122, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Liu, Yun-Hui
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurosurg, Shengjing Hosp, Shenyang 110004, Peoples R China
Liaoning Res Ctr Translat Med Nervous Syst Dis, Shenyang 110004, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Cai, Heng
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurosurg, Shengjing Hosp, Shenyang 110004, Peoples R China
Liaoning Res Ctr Translat Med Nervous Syst Dis, Shenyang 110004, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Ma, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
China Med Univ, Inst Pathol & Pathophysiol, Shenyang 110122, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Liu, Li-Bo
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
China Med Univ, Inst Pathol & Pathophysiol, Shenyang 110122, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Xi, Zhuo
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurosurg, Shengjing Hosp, Shenyang 110004, Peoples R China
Liaoning Res Ctr Translat Med Nervous Syst Dis, Shenyang 110004, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Li, Zhi-Qing
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
China Med Univ, Inst Pathol & Pathophysiol, Shenyang 110122, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Liu, Xiao-Bai
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurosurg, Shengjing Hosp, Shenyang 110004, Peoples R China
Liaoning Res Ctr Translat Med Nervous Syst Dis, Shenyang 110004, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China

Xue, Yi-Xue
论文数: 0 引用数: 0
h-index: 0
机构:
China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
China Med Univ, Inst Pathol & Pathophysiol, Shenyang 110122, Peoples R China China Med Univ, Dept Neurobiol, Coll Basic Med, Shenyang 110122, Peoples R China
[28]
MicroRNA-383-5p acts as a prognostic marker and inhibitor of cell proliferation in lung adenocarcinoma by cancerous inhibitor of protein phosphatase 2A
[J].
Zhao, Shasha
;
Gao, Xinyuan
;
Zang, Shuzhi
;
Li, Yunxia
;
Feng, Xianjun
;
Yuan, Xiaomei
.
ONCOLOGY LETTERS,
2017, 14 (03)
:3573-3579

Zhao, Shasha
论文数: 0 引用数: 0
h-index: 0
机构:
Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China

Gao, Xinyuan
论文数: 0 引用数: 0
h-index: 0
机构:
Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China

Zang, Shuzhi
论文数: 0 引用数: 0
h-index: 0
机构:
Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China

Li, Yunxia
论文数: 0 引用数: 0
h-index: 0
机构:
Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China

Feng, Xianjun
论文数: 0 引用数: 0
h-index: 0
机构:
Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China

Yuan, Xiaomei
论文数: 0 引用数: 0
h-index: 0
机构:
Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China Xinxiang Med Coll, Hosp 1, Dept Resp Med, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China