A new chromone from Kandelia candel endophytic fungus Aspergillus sp. ZJ-68

被引：2

作者：

Liu, Wen-Bin ^{[1
]}

Tang, Jing ^{[1
]}

Li, Jia-Lin ^{[1
]}

Chen, Chen ^{[1
]}

Wu, Li ^{[1
]}

Li, Jun-Sen ^{[1
]}

Long, Yu-Hua ^{[1
]}

机构：

[1] South China Normal Univ, Sch Chem, Guangzhou Key Lab Analyt Chem Biomed, GDMPA Key Lab Proc Control & Qual Evaluat Chiral P, Guangzhou 510631, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Chromone; anti-inflammatory; mangrove fungi; secondary metabolites;

D O I：

10.1080/10286020.2023.2197226

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One chromone (1), together with four known alkaloids, were isolated from the mangrove endophytic fungus Aspergillus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses. Compound 1 showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 4.094 +/- 0.8 mu M, which was better than positive drug indomethacin (IC50=35.8 +/- 0.5 mu M). [GRAPHICS] .

引用

页码：1125 / 1131

页数：7

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