A new chromone from Kandelia candel endophytic fungus Aspergillus sp. ZJ-68

被引：1
|
作者：
Liu, Wen-Bin [1 ]
Tang, Jing [1 ]
Li, Jia-Lin [1 ]
Chen, Chen [1 ]
Wu, Li [1 ]
Li, Jun-Sen [1 ]
Long, Yu-Hua [1 ]
机构：
[1] South China Normal Univ, Sch Chem, Guangzhou Key Lab Analyt Chem Biomed, GDMPA Key Lab Proc Control & Qual Evaluat Chiral P, Guangzhou 510631, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Chromone; anti-inflammatory; mangrove fungi; secondary metabolites;
D O I：
10.1080/10286020.2023.2197226
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
One chromone (1), together with four known alkaloids, were isolated from the mangrove endophytic fungus Aspergillus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses. Compound 1 showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 4.094 +/- 0.8 mu M, which was better than positive drug indomethacin (IC50=35.8 +/- 0.5 mu M). [GRAPHICS] .
引用
收藏
页码：1125 / 1131
页数：7
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