Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

被引：2
|
作者：
Ono, Takahiro [1 ]
Tabata, Kazuhito V. [2 ]
Noji, Hiroyuki [2 ,3 ]
Morimoto, Jumpei [1 ]
Sando, Shinsuke [1 ,3 ]
机构：
[1] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
[2] Univ Tokyo, Grad Sch Engn, Dept Appl Chem, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
[3] Univ Tokyo, Grad Sch Engn, Dept Bioengn, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
来源：
RSC ADVANCES | 2023年 / 13卷 / 12期
基金：
日本科学技术振兴机构;
关键词：
MEMBRANE-PERMEABILITY; CONFORMATION; ABSORPTION; ASSAY;
D O I：
10.1039/d3ra01358h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.
引用
收藏
页码：8394 / 8397
页数：4
相关论文
共 45 条
  • [1] Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers
    Ono, Takahiro
    Tabata, Kazuhito V.
    Goto, Yuki
    Saito, Yutaro
    Suga, Hiroaki
    Noji, Hiroyuki
    Morimoto, Jumpei
    Sando, Shinsuke
    CHEMICAL SCIENCE, 2023, 14 (02) : 345 - 349
  • [2] Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers
    Ono, Takahiro
    Tabata, Kazuhito V.
    Goto, Yuki
    Saito, Yutaro
    Suga, Hiroaki
    Noji, Hiroyuki
    Morimoto, Jumpei
    Sando, Shinsuke
    Chemical Science, 2022, 14 (02): : 345 - 349
  • [3] Theory of passive permeability through lipid bilayers
    Nagle, John F.
    Mathai, John C.
    Zeidel, Mark L.
    Tristram-Nagle, Stephanie
    JOURNAL OF GENERAL PHYSIOLOGY, 2008, 131 (01): : 77 - 85
  • [4] Passive Permeability of Planar Lipid Bilayers to Organic Anions
    Ebert, Andrea
    Hannesschlaeger, Christof
    Goss, Kai-Uwe
    Pohl, Peter
    BIOPHYSICAL JOURNAL, 2018, 115 (10) : 1931 - 1941
  • [5] Passive diffusion of polymeric surfactants across lipid bilayers
    Mathot, Frederic
    Schanck, A.
    Van Bambeke, F.
    Arien, A.
    Noppe, M.
    Brewster, M.
    Preat, V.
    JOURNAL OF CONTROLLED RELEASE, 2007, 120 (1-2) : 79 - 87
  • [6] Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers
    Runas, Kristina A.
    Malmstadt, Noah
    SOFT MATTER, 2015, 11 (03) : 499 - 505
  • [7] Conformational change of cholesterol side chain in lipid bilayers
    1600, (113):
  • [8] Microfluidic Measurement of Carbon Dioxide Permeability across Lipid Bilayers
    Blosser, Matthew C.
    Madani, Majed S.
    So, Justin
    Malmstadt, Noah
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 229A - 229A
  • [9] Permeability of Boric Acid Across Lipid Bilayers and Factors Affecting It
    C. Dordas
    P.H. Brown
    The Journal of Membrane Biology, 2000, 175 : 95 - 105
  • [10] PERMEABILITY OF WATER-MOLECULES ACROSS VESICULAR LIPID BILAYERS
    LAWACZECK, R
    JOURNAL OF MEMBRANE BIOLOGY, 1979, 51 (3-4): : 229 - 261
12345