Roles of TGF-β signalling pathway-related lncRNAs in cancer (Review)

被引：8

作者：

Hu, Zhizhong ^{[1
]}

Liu, Yitong ^{[1
]}

Liu, Meiqi ^{[1
]}

Zhang, Yang ^{[1
,2
]}

Wang, Chengkun ^{[1
,2
]}

机构：

[1] Univ South China, Canc Res Inst, Med Sch, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Canc Res Inst, Med Sch, 28 Chang Sheng Xi Ave, Hengyang 421001, Hunan, Peoples R China

来源：

ONCOLOGY LETTERS | 2023年 / 25卷 / 03期

基金：

中国国家自然科学基金;

关键词：

cancer; lncRNA; TGF-beta signalling pathway; LONG NONCODING RNA; CELL LUNG-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; DOWN-REGULATION; COLORECTAL-CANCER; GASTRIC-CANCER; PROMOTES PROLIFERATION; UBIQUITIN LIGASE; GROWTH; PROGRESSION;

D O I：

10.3892/ol.2023.13693

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs (lncRNAs) are a class of RNAs that are > 200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tumour progression; these pathways include the transforming growth factor (TGF)-beta signalling pathway, which is related to tumour development. The expression of lncRNAs in various tumour tissues is specific, and their interaction with the TGF-beta signalling pathway indicates that they may serve as new tumour markers and therapeutic targets. The present review summarized the role of TGF-beta pathway-associated lncRNAs in regulating tumorigenesis in different types of cancer and their effects on the TGF-beta signalling pathway.

引用

页数：15

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