Research Progress on the Effect of Autophagy and Exosomes on Liver Fibrosis

被引：4
作者：
Du, Yikuan [1 ]
Zhu, Silin [2 ]
Zeng, Haojie [2 ]
Wang, Zhenjie [2 ]
Huang, Yixing [2 ]
Zhou, Yuqi [2 ]
Zhang, Weichui [2 ]
Zhu, Jinfeng [2 ]
Yang, Chun [2 ,3 ]
机构：
[1] Southern Med Univ, Affiliated Dongguan Hosp, Cent Lab, Dongguan 523059, Peoples R China
[2] Guangdong Med Univ, Dongguan Key Lab Stem Cell & Regenerat Tissue Engn, Dongguan 523808, Peoples R China
[3] Guangdong Med Univ, Dongguan Affiliated Hosp 1, Dongguan 523716, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2024年 / 19卷 / 06期
关键词：
Exosomes; microRNA; autophagy; liver fibrosis; target of rapamycin; hepatic stellate cell; HEPATIC STELLATE CELL; MESENCHYMAL STEM-CELLS; DIABETIC-NEPHROPATHY; SIGNALING PATHWAY; ACTIVATION; FERROPTOSIS; MODULATION; CONTRIBUTE; MICRORNAS; TISSUE;
D O I：
10.2174/1574888X18666230427112930
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Chronic liver disease is a known risk factor for the development of liver cancer, and the development of microRNA (miRNA) liver therapies has been hampered by the difficulty of delivering miRNA to damaged tissues. In recent years, numerous studies have shown that hepatic stellate cell (HSC) autophagy and exosomes play an important role in maintaining liver homeostasis and ameliorating liver fibrosis. In addition, the interaction between HSC autophagy and exosomes also affects the progression of liver fibrosis. In this paper, we review the research progress of mesenchymal stem cell-derived exosomes (MSC-EVs) loaded with specific miRNA and autophagy, and their related signaling pathways in liver fibrosis, which will provide a more reliable basis for the use of MSC-EVs for therapeutic delivery of miRNAs targeting the chronic liver disease.
引用
收藏
页码：785 / 797
页数：13
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